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Activation, Metabolism and Perfusion of the Heart pp 41–59Cite as

Parasympathetic control of the SA node cell in rabbit heart — a model

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 70))

Abstract

A mathematical model of the sinoatrial (SA) node cell based on the modeling studies of Di Francesco and Noble [1] for the Purkinje fiber, and Noble and Noble [2] for the rabbit SA node, is developed along with models of the utilization of the autonomic neurotransmitters acetylcholine and norepinephrine by elements of the cell membrane. Studies of the phase-sensitivity for the SA node cell model to vagal burst stimulation are conducted, with and without a constant background level of norepinephrine. The results reported are of a preliminary nature, but they mimic published data regarding the free-running behavior of the primary cells of the SA node as well as, their response to phasic vagal burst stimuli.

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Authors
  1. C. R. Murphey
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  2. J. W. Clark Jr
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Editor information

Editors and Affiliations

  1. Rutgers Medical School, Rutgers State University, Piscataway, NJ, 08854, USA

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering)

  2. Department of Biomedical Engineering Technion, Israel Institute of Technology, Haifa, 3200, Israel

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) & R. Beyar M.D., D.Sc. (Senior Lecturer) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) &  (Senior Lecturer)

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Murphey, C.R., Clark, J.W. (1987). Parasympathetic control of the SA node cell in rabbit heart — a model. In: Sideman, S., Beyar, R. (eds) Activation, Metabolism and Perfusion of the Heart. Developments in Cardiovascular Medicine, vol 70. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3313-2_3

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  • DOI: https://doi.org/10.1007/978-94-009-3313-2_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7987-7

  • Online ISBN: 978-94-009-3313-2

  • eBook Packages: Springer Book Archive

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