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Influence of pacing site on ventricular mechanics

  • Chapter
Activation, Metabolism and Perfusion of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 70))

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Abstract

We investigated the influence of pacing site on several aspects of left ventricular (LV) performance to test the hypothesis that the ‘effective ventricular muscle Mass’ is reduced with direct ventricular pacing. All studies were performed on isolated supported canine hearts which were constrained to contract isovolumically. We observed significant influence of pacing site on the magnitude, but not the time course of isovolumic ventricular pressure waves. Pacing from different sites of the ventricle resulted in different chamber contractile strengths. There was a linear inverse relation between changes in QRS duration and changes in contractile strength. The decreased chamber contractility manifests itself as a decrease in the slope (Ees) and a small increase in the volume-axis intercept (Vo) of the end-systolic pressure-volume relation. The relation between ventricular oxygen consumption and pressure-volume area was independent of pacing site. These results are consistent with the hypothesis that the effective mass of muscle which participates in the generation of active contractile strength is reduced when the pacing site is moved from the atrium to the ventricle.

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Authors
  1. D. Burkhoff
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  2. W. L. Maughan
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Editor information

Editors and Affiliations

  1. Rutgers Medical School, Rutgers State University, Piscataway, NJ, 08854, USA

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering)

  2. Department of Biomedical Engineering Technion, Israel Institute of Technology, Haifa, 3200, Israel

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) & R. Beyar M.D., D.Sc. (Senior Lecturer) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) &  (Senior Lecturer)

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Burkhoff, D., Maughan, W.L. (1987). Influence of pacing site on ventricular mechanics. In: Sideman, S., Beyar, R. (eds) Activation, Metabolism and Perfusion of the Heart. Developments in Cardiovascular Medicine, vol 70. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3313-2_10

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  • DOI: https://doi.org/10.1007/978-94-009-3313-2_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7987-7

  • Online ISBN: 978-94-009-3313-2

  • eBook Packages: Springer Book Archive

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