Structural component of vascular resistance in hypertension

  • Björn Folkow
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 63)


All biologic tissues are able to adapt their design, though in their own characteristic way, whenever sustained changes of activity or/and load occur, a process often modified also by ‘trophic’ influences as by local and blood-borne humoral agents and nerve transmitters. For example, it is well known that the design of the skeletal muscle system, being basically genetically determined as expressed in ‘leptosomic’ or ‘mesomorphic’ constitutions, is considerably affected not only by the duration, frequency and intensity of imposed physical training but also by trophic influences, as shown by the effects of anabolic steroids when abused in modern athletics. It is also well known that relative inactivity soon leads to regression of muscle hypertrophy and, when severe, even to atrophy.


Resistance Vessel Resistance Curve Primary Hypertension Glyceryl Ether Smooth Muscle Activity 
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© Martinus Nijhoff Publishers, Dordrecht. 1987

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  • Björn Folkow

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