Abstract
Chromosome 21 (HSA21) is the smallest human chromosome and contains about 1.8% of genomic DNA (1). The decisive process for manifestation of trisomy 21 (Ts21) is the triplication of the distal band 21q22 (2), which is known to carry the genes for a proto-oncogene sequence (ETS2) and the enzymes superoxide dismutase (SOD1) and phosphoribosylglycinamide synthetase (PRGS) (3,4). A regional localization has been described for the gene for phosphofructokinase (PFKL) (5,6). It is not yet known which genes are responsible for manifestation of Down’s syndrome. However, up to now, eight individual genes have been localized, which — besides those located on band 21q22 — are distributed over the entire chromosome (for appropriate surveys see 1).
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© 1988 Martinus Nijhoff Publishers, Dordecht
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Bacchus, C., Buselmaier, W. (1988). Blastomere Karyotyping: A Direct Method for Producing Mouse Trisomy 16 ↔ Diploid Aggregation Chimeras as an Animal Model of Human Down’s Syndrome. In: Beynen, A.C., Solleveld, H.A. (eds) New Developments in Biosciences: Their Implications for Laboratory Animal Science. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3281-4_65
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DOI: https://doi.org/10.1007/978-94-009-3281-4_65
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