Abstract
In the initial hours following a ‘heart attack’, as many as 50% of subjects die from ventricular fibrillation or acute left ventricular failure. For the survivors who reach hospital, or who are treated at home, left ventricular function, reflecting the amount of viable myocardium that remains, is the single most important determinant of both short and long term morbidity and mortality. Patients with large infarctions will tend to demonstrate poor left ventricular function and a high percentage will develop cardiogenic shock, late ventricular tachyarrhythmias, or subsequent (often unheralded) ventricular fibrillation. Though coronary care units, introduced in the early 1960s, have decreased the in-hospital mortality from arrhythmias, in the 1970s there was only a slight reduction in mortality from the other principal causes of death, such as cardiogenic shock, heart failure or further myocardial infarction. The recent introduction of an aggressive early interventional approach to the management of acute myocardial infarction offers some hope for future patients.
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References
Braunwald, E. (1967). Pathogenesis and treatment of shock in myocardial infarction. Johns Hopkins Med. J., 121, 421–9
Rude, R. E., Muller, J. E. and Braunwald, E. (1981). Efforts to limit the size of myocardial infarcts. Ann. Intern. Med., 95, 736–61
Alpert, J. S. and Braunwald, E. (1984). Acute myocardial infarction: pathological, pathophysiological and clinical manifestations. In Braunwald, E. (ed.) Heart Disease, pp. 1262–1300 (Eastbourne: Saunders)
Brush, J. E., Brand, D. A., Acampora D., Chalmer B. and Wackers, F. J. (1985). Use of initial electrocardiogram to predict in-hospital complications of acute myocardial infarction. N. Engl. J. Med., 312, 1137–41
Norris, R.M., Brandt, P.W.T., Caughey, D.E., Lee, A.J. and Scott, P.J. (1969). A new coronary prognostic index. Lancet, 1, 274–8
Sobel, B. E. and Braunwald, E. (1984). The management of acute myocardial infarction. In Braunwald, E. (ed.) Heart Disease, pp. 1301–1333 (Eastbourne: Saunders)
Goldman, L., Cook, F., Hashimoto, B., Stone, P., Muller, J. and Loscalzo, A. (1982). Evidence that hospital care for acute myocardial infarction has not contributed to the decline in coronary mortality between 1973–74 and 1978–79. Circulation, 65, 936–42
Gruppo Italiano per lo studio della streptochinasi nelľinfarcto miocardico (GISSI). (1986). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet, 1, 397–401
Rentrop, K.P. (1985). Thrombolytic therapy in patients with acute myocardial infarction. Circulation, 71, 627–631
Laffel, G. L., Braunwald, E. (1984). Thrombolytic therapy. A new strategy for the treatment of acute myocardial infarction (2 parts). N. Engl. J. Med., 311, 710–17 and 770–6
Yusuf, S., Collins, R., Peto, R., Furberg, C., Stampfer, M. J., Goldhaber, S. Z. and Hennekens, C. H. (1985). Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of the results on mortality, reinfarction and side effects from 33 randomised controlled trials. Eur. Heart. J., 6, 556–85
Kennedy, J.W., Richie, J.L., Davis, K.B. and Fritz, J.K. (1983). Western Washington randomised trial of intracoronary streptokinase in acyte myocardial infarction. N. Engl. J. Med, 309, 1477–81
Thrombolysis in Myocardial Infarction Study Group. (1985). The thrombolysis in acute myocardial infarction (TIMI) trial. Phase 1 findings. N. Engl. J. Med., 312, 932–6
Simoons, M.L., Serruys, P. W., Brand, M. V., Bar, F., DeZwaan, C., et al. (1985). Improved survival after thrombolysis in acute myocardial infarction. Lancet, 2, 578–81
Verstraete, M., Bory, M., Collen, D., Bernard, R., Brower, R.W. et al. (1985). Randomised trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction. Report from the European study group for recombinant tissue-type plasminogen activator. Lancet, 1, 842–7
Meyer, J., Merx, W., Schmitz, H., Erbel, R., Kiesslich, T., Dorr, R., Lanbertz, H. et al. (1982). Percutaneous transluminal coronary angioplasty immediately after intra-coronary streptolysis of transmural myocardial infarction. Circulation, 66, 905–13
Hartzler, G. O., Rutherford, B. D., McConahay, D. R., Johnson, W. L. Jr, McCallister, B. D., Gura, G. M., Conn, R. C. and Crockett, J. E. (1983). Percutaneous transluminal coronary angioplasty with and without thrombolytic therapy for treatment of acute myocardial infarction. Am. Heart. J., 106, 965–73
DeWood, M. A. and Berg, R. Jr. (1984). The role of surgical reperfusion in myocardial infarction. In Roberts, R. (ed.). Prognosis after myocardial infarction. Cardiology Clinics, 2: (1), pp. 113–22. (Philadelphia: W. B. Saunders Co)
Gray, R. J., Sethna, D. and Matloff, J. M. (1983). The role of cardiac surgery in acute myocardial infarction. II Without mechanical complications. Am. Heart. J., 106, 728–35
Schuster, E. H. and Bulkley, B. H. (1981). Early post infarction angina. N. Engl. J. Med., 305, 1101–5
Gray, R.J., Sethna, D. and Matloff, J. M. (1983). The role of cardiac surgery in acute myocardial infarction. I. With mechanical complications. Am. Heart. J., 106, 723–8
Yusuf, S., Peto, R., Lewis, J., Collins, R. and Sleight, P. (1985). Beta blockade during and after myocardial infarction: An overview of the randomised trials. Prog. Cardiovasc. Dis., 27, 335–71
The MIAMI trial research group. Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial. Eur. Heart. J. 1985; 6, 199–226
Muller, J. E. and Braunwald, E. (1983). Can infarct size be limited in patients with acute myocardial infarction? Cardiovasc. Clin., 13(1), 147–61
The Danish Study Group on verapamil in acute myocardial infarction. Verapamil in Acute Myocardial Infarction. Eur. Heart. J., 1984; 5, 516–28
Muller, J.E., Morrison, J., Stone, P.H., Rude, R.E., Rosner, B. et al. (1984). Nifedepine therapy for patients with threatened and acute myocardial infarction: a randomised, double blind, placebo controlled comparison. Circulation, 69, 740–7
Quinones, M. A. (1984). Echocardiography in acute myocardial infarction. Cardiol. Clin., 2(1), 123–34
Epstein, S. E., Palmeri, S. T. and Patterson, R. D. (1982). Evaluation of patients after acute myocardial infarction. Indications for cardial catheterisation and surgical intervention. N. Engl. J. Med., 307, 1487–92
Maisel, A. S., Ahvre, S., Gilpin, E., Henning, H., Goldberger, A. L., Collins, D., LeWinter, M. and Ross, J. Jr. (1985). Prognosis after extension of myocardial infarct: the role of Q wave or non-Q wave infarction. Circulation, 71, 211–17
Roberts, R. and Marmor, A. T. (1983). Right ventricular infarction. Ann. Rev. Med., 34, 377–90
May, G.S., Furberg, C.D., Eberlain, K.A. and Geraci, B.J. (1983). Secondary prevention after acute myocardial infarction: a review of the short term acute phase trials. Prog. Cardiovasc. Dis., 25, 335–59
May, G. S., Eberlein, K.A., Furberg, C. D., Passamani, E. R. and DeMets, D.L. (1982). Secondary prevention after myocardial infarction. A review of long-term trials. Prog. Cardiovasc. Dis., 24, 331–52
Graboys, D. B. (1975). In hospital sudden death after coronary care unit discharge: A high risk profile. Arch. Intern. Med., 135, 512–4
Denniss, A. R., Baaijens, H., Cody, D. V., Richards, D. A., Russell, P. A., Young, A. A., Ross, D.L. and Uther, J.B. (1985). Value of programmed stimulation and exercise testing in predicting one year mortality after acute myocardial infarction. Am. J. Cardiol., 56, 213–20
Baron, D. B., Light, J. R. and Ellestad, M. H. (1984). Status of exercise stress testing after myocardial infarction. Arch. Intern. Med., 144, 595–601
Cohn, P. F. (1983). The role of non-invasive cardiac testing after an uncomplicated myocardial infarction. N. Engl. J. Med., 308, 90–3
Weld, F.M., Chu, K.L. and Bigger, J.T. (1981). Risk stratification with low level exercise testing two weeks after acute myocardial infarction. Circulation, 64, 306–14
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Ilsley, C.D.J., Ablett, M.B. (1987). Investigation and management of acute myocardial infarction. In: Fox, K.M. (eds) Ischaemic Heart Disease. Current Status of Clinical Cardiology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3211-1_8
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DOI: https://doi.org/10.1007/978-94-009-3211-1_8
Publisher Name: Springer, Dordrecht
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