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A neurodevelopmental perspective on brain pathology in schizophrenia

  • D. R. Weinberger

Abstract

Most neurobiological hypotheses about schizophrenia hold that the characteristic symptoms reflect dysfunction of the brain and that this dysfunction is the result of brain disease. It is generally assumed that there is a simple temporal relationship between the onset of the disease process and the clinical presentation of the illness. In other words, it is assumed that as the disease occurs, brain function is impaired and, pari passu, illness is manifest. This view would be consistent with the notion that schizophrenia is caused by a metabolic disorder or dysfunction of neural transmission, or with the notion that schizophrenia results from some episode of brain trauma such as might happen following viral encephalitis. It is also consistent with the possibility that schizophrenia is a progressive neurodegenerative disorder. To the extent that there is a genetic component to the illness, this may involve susceptibility to the disease process or the expression during early adult life of a genetically determined pathophysiology.

Keywords

Prefrontal Cortex Cerebral Palsy Compute Tomography Finding Brain Pathology Ventricular Enlargement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1987

Authors and Affiliations

  • D. R. Weinberger

There are no affiliations available

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