Abstract
Continuous infusion of chemotherapy agents into the arterial system of the liver has several theoretical advantages. The continuous administration of chemotherapy to the tumor prolongs drug exposure to the tumor cells undergoing DNA synthesis, thus increasing the cell-kill fraction. Previous anatomical studies in laboratory animals and humans have demonstrated that most hepatic tumors derive a majority of their blood supply from the hepatic artery as opposed to the portal vein.1,2 This phenomenon, along with the ability of the liver to metabolize certain chemotherapeutic drugs, allows a much higher local concentration of drug to reach the tumor, with reduced systemic effects. The extensive clinical experience with regional hepatic arterial therapy in the treatment of primary and metastatic liver tumors by means of extracorporeal pump devices is reviewed elsewhere in this volume. Suffice it to say that long-term ambulatory therapy with such systems remains inconvenient and has been associated with mechanical and infectious complications.3
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Proceedings from 3rd Saddlebrook Conf: ongoing clinical trials using a totally implantable drug delivery system. Feb 1985. Spons by Intermedics Infusaid, Inc., Norwood, MA.
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Chang, A.E., Schneider, P.D., Sugarbaker, P.H. (1987). Hepatic Arterial Infusion Chemotherapy: Clinical Trials with the Implantable Pump. In: Cancer Chemotherapy by Infusion. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3193-0_33
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DOI: https://doi.org/10.1007/978-94-009-3193-0_33
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7932-7
Online ISBN: 978-94-009-3193-0
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