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Part of the book series: Current Histopathology ((CUHI,volume 13))

Abstract

Many of the induced changes in the endocrine system are a result of interference with feedback control mechanisms and as such are often predictable. However, some lesions also occur which are due to direct toxic effects.

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References

Adrenals

  1. Ribelin, W.E.(1984). Theeffects of drugs and chemicals upon the structure of the adrenal gland. Furidam. Appl. Toxicol. 4 105–119.

    Article  CAS  Google Scholar 

  2. Colby, H. D. and Eacho, P. I. (1985). Chemical induced adrenal injury: role of metabolic activation. In Thomas, J. A., Korach, K. S. and McLachlan, J. A. (eds.) Endocrine Toxicology pp. 35–66. (New York: Raven)

    Google Scholar 

  3. Yarrington, J. T. (1983). Chemically induced adrenocortical lesions. In Jones, T. C., Mohr, U. and Hunt, R. D. (eds.) Endocrine System. Monographs on Pathology of Laboratory Animals pp. 69–75. (Berlin and Heidelberg: Springer-Verlag)

    Google Scholar 

  4. Deane, H. W., Shaw, J. H. and Greep, R. O. (1948). The effect of altered sodium or potassium intake on the width and cytochemistry of the zona glomerulosa of the rats adrenal cortex. Endocrinology, 43, 133–153.

    Article  PubMed  CAS  Google Scholar 

  5. Goldman, M. I., Ronzoni, E. and Schroeder, H. A. (1956). The response of the adrenal cortex of the rat to dietary salt restriction and replacement. Endocrinology 58 57–61.

    Article  PubMed  CAS  Google Scholar 

  6. Davis, D. A. and Medline, N. M. (1970). Spironolactone (Aldactone) bodies: concentric lamellar formations in the adrenal cortices of patients treated with Spironolactone. Am. J. Clin. Pathol. 54 22–32.

    PubMed  CAS  Google Scholar 

  7. Abbott, E. C., Monkhouse, F. C., Steiner, J. W. and Laidlaw, J. C. (1966). Effect of a sulphated mucopolysaccharide (R01–8307) on the zona glomerulosa of the rat adrenal gland. Endocrinology, 78, 651–654.

    Article  PubMed  CAS  Google Scholar 

  8. Mazzocchi, G. and Nussdorfer, G. G. (1984). Long-term effects of captopril on the morphology of normal rat adrenal zona glomerulosa. Exp. Clin. Endocrinol., 84, 148–152.

    Article  PubMed  CAS  Google Scholar 

  9. Robba, C., Mazzocchi, G. and Nussdorfer, G. G. (1986). Further studies on the inhibitory effects of somatostatin on the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Exp. Pathol. 29, 77–82.

    PubMed  CAS  Google Scholar 

  10. Rebuffat, P., Robba, C., Mazzocchi, G. and Nussdorfer, G. G. (1984). Inhibitory effect of somatostatin on the growth and steroidogenic capacity of rat adrenal zona glomerulosa. J. Steroid. Biochem. 21, 387–390.

    Article  PubMed  CAS  Google Scholar 

  11. Kovács, K., Carroll, R. and Tapp, E.(1966). The pathogenesis of hexadimethrine necrosis of the pituitary and adrenal. Arzneim — Forsch., 16, 516–519.

    Google Scholar 

  12. Pudney, J., Price, G. M., Whitehouse, B. J. and Vinson, G. P. (1984). Effects of chronic ACTH stimulation on the morphology of the rat adrenal cortex. Anat. Rec. 210, 603–615.

    Article  PubMed  CAS  Google Scholar 

  13. Rhodin, J. A. G. (1971). The ultrastructure of the adrenal cortex of the rat under normal and experimental conditions. J. Ultrastruct. Res. 34, 23–71.

    Article  PubMed  CAS  Google Scholar 

  14. Wernert, N., Antalffy, A. and Dhom, G. (1986). Effects of estradiol on adrenal cortex and medulla of the rat. Pathol. Res. Pract. 181, 551–557.

    PubMed  CAS  Google Scholar 

  15. Wyllie, A. H., Kerr, J. F. R., Macaskill, I. A. M. and Currie, A. R. (1973). Adrenocortical cell deletion: the role of ACTH. J. Pathol., 111, 85–94.

    Article  PubMed  CAS  Google Scholar 

  16. Nussdorfer, G. G. (1970). Effects of corticosteroid hormones on the smooth endoplasmic reticulum of rat adrenocortical cells. Z Zellforsch., 106, 143–154.

    Article  CAS  Google Scholar 

  17. El Etreby, M. F., Gräf, K. J., Gunzel, P. and Neumann, F. (1979). Evaluation of effects of sexual steroids on the hypothalmic pituitary system of animals and man. Arch. Toxicol. Suppl. 2, 11–39.

    Google Scholar 

  18. Nelson, L. W. and Kelly, W. A. (1976). Progestogen-related gross and microscopic changes in female beagles. Vet. Pathol. 13 143–156.

    PubMed  CAS  Google Scholar 

  19. Szabo, S., McComb, D. J., Kovács, K. and Hüttner, I. (1981). Adrenocortical hemorrhagic necrosis. Arch. Pathol. Lab. Med. 105, 536–539.

    PubMed  CAS  Google Scholar 

  20. Szabo, S., Hüttner, I., Kovács, K., Horvath, E., Szabo, D. and Horner, H. C. (1980). Pathogenesis of experimental adrenal hemorrhagic necrosis (‘apoplexy’). Lab. Invest. 42, 533–546.

    PubMed  CAS  Google Scholar 

  21. Yarrington, J. T., Loudy, D. E., Sprinkle, D. J., Gibson, J. P., Wright, C. L. and Johnston, J. O. (1985). Degeneration of the rat and canine adrenal cortex caused by α-(1,4-dioxido-3- methylquinoxalin-2-yl)-N-methylnitrone (DMNM). Fundam. Appl. Toxicol. 5, 370–381.

    Article  PubMed  CAS  Google Scholar 

  22. Yarrington, J. T., Huffmann, K. W. and Gibson, J. P. (1981). Adrenocortical degeneration in dogs, monkeys and rats treated with α-(1,4-dioxido-3-methylquinoxalin-2-yl)-N-methylnitrone. Toxicol. Lett., 8, 229–234.

    Article  PubMed  CAS  Google Scholar 

  23. Hart, M. M., Reagan, R. L. and Adamson, R. H. (1973). The effect of isomers of DDD on the ACTH-induced steroid outputhistology and ultrastructure of the dog adrenal cortex. Toxicol. Appl. Pharmacol., 24, 101–113.

    Article  PubMed  CAS  Google Scholar 

  24. Dhom, G., Hohbach, Ch., Mäusle, E., Scherr, O. and Ueberberg, H. (1981). Peliosis of the female adrenal cortex of the aging rat. Virchows Arch. B: ZellpathoL, 36, 195–206.

    Article  CAS  Google Scholar 

  25. Daft, F. S., Sebrell, W. H., Babcock, S. H. and Jukes, T. H. (1940). Effect of synthetic pantothenic acid on adrenal hemorrhage, atrophy and necrosis in rats. Public Health Rep., 55, 1333–1346.

    Article  CAS  Google Scholar 

  26. Zak, F. (1983). Lipid hyperplasia, adrenal cortex, rat. In Jones, T. C., Mohr, U. and Hunt, R. D. (eds.) Endocrine System. Monographs on Pathology of Laboratory Animals pp. 80–84. (Berlin, Heidelberg: Springer-Verlag)

    Google Scholar 

  27. Lüllmann-Rauch, R. and Reil, G-H. (1974). Chlorphentermine-induced lipidosis-like ultrastructural alterations in lungs and adrenal glands of several species. Toxicol. Appl. Pharmacol. 30, 408–421.

    Article  PubMed  Google Scholar 

  28. Bockhardt, H. and Lüllmann-Rauch, R. (1980). Zimelidine-in-duced lipidosis in rats. Acta Pharmacol. Toxicol. 47, 45–48.

    Article  CAS  Google Scholar 

  29. Motlik, K., Krawczynski, K. and Nowoslawski, A. (1968). Experimental hyaline droplets in the rat adrenal cortex. Virchows Arch. A: Pathol. Anat., 344, 331–345.

    Article  Google Scholar 

  30. Greenman, D. L., Highman, B. and Kodell, R. L. (1984). Neoplastic and nonneoplastic responses to chronic feeding of diethylstilbestrol in CBH mice. J. Toxicol. Environ. Health 14, 551–567.

    Article  PubMed  CAS  Google Scholar 

  31. Moore, N. A. and Callas, G. (1975). Observations on the fine structure of propylthiouracil induced ‘brown degeneration’ in the zona reticularis of mouse adrenal cortex. Anat. Ree., 183, 293–302.

    Article  CAS  Google Scholar 

  32. Surleff, S. V. and Papadimitrion, J. M. (1981). The mononuclear phagocytes of the rat adrenal. Am. J. Pathol., 104, 258–271.

    PubMed  CAS  Google Scholar 

  33. Roe, F. J. C. and Bär, A. (1985). Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption. Human Toxicol. 4, 27–52.

    Article  CAS  Google Scholar 

  34. Boelsterli, U. A. and Zbinden, G. (1985). Early biochemical and morphological changes of the rat adrenal medulla induced by xylitol. Arch. Toxicol. 57, 25–30.

    Article  PubMed  CAS  Google Scholar 

  35. Kurokawa, Y., Hayashi, Y., Maekawa, A., Takahashi, M. and Kukubo, T. (1985). High incidence of phaeochromocytomas after long term administration of retinol acetate to F344/DuCrj rats. J. Natl. Cancer Inst., 74, 715–723.

    PubMed  CAS  Google Scholar 

  36. McConnell, E. E. and Tally, F. A. (1977). Intracytoplasmic hyaline globules in the adrenal medulla of laboratory animals. Vet. Pathol., 14, 435–40.

    Google Scholar 

Islets of Langerhans

  1. Fischer, L. J. and Rickert, D. E. (1975). Pancreatic islet-cell toxicity. CRC. Crit. Rev. Toxicol. 4, 231–262.

    Article  Google Scholar 

  2. Rerup, C. C. (1970). Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol. Rev., 22, 484–518.

    Google Scholar 

  3. Mukai, K. and Rosai, J. (1980). Applications of immunoperoxidase techniques in surgical pathology. In Fenoglio, C. M. and Wolff, M. (eds.) Progress in Surgical Pathology. Vol. I, pp. 15–49. (New York: Masson Publ. Inc.)

    Google Scholar 

  4. Greaves, P. and Faccini, J. M. (1984). Endocrine glands. In Rat Histopathology. pp. 187–210. (Amsterdam: Elsevier)

    Google Scholar 

  5. Orci, L. (1984). Patterns of cellular and subcellular organisation in the endocrine pancreas. J. Endocrinol., 102, 3–11.

    Article  PubMed  CAS  Google Scholar 

  6. Biollot, D., in’t Veld, P., Sai, P., Feutren, G„ Gepts, W. and Assan, R. (1985). Functional and morphological modifications induced in rat islets by pentamidine and other diamides in vitro. Diabetologia, 28, 359–364.

    Google Scholar 

  7. Nelson, L. W. and Kelly, W. A. (1976). Progestogen-related gross and microscopic changes in female beagles. Vet. Pathol., 13, 143–156.

    PubMed  CAS  Google Scholar 

  8. Tucker, M. J. (1971). Some effects of prolonged administration of a progestogen to dogs. Proc. Eur. Soc. Study Drug Toxic., 12, 228–238.

    CAS  Google Scholar 

  9. McClure, M. M., Chapman, W. L., Hooper, B. E., Smith, F. G. and Fletcher, O.J. (1978). The digestive system. In Benirschke, K., Garner, F. M. and Jones, T. C. (eds.) Pathology of Laboratory Animals. Vol. I, pp. 175–318. (New York: Springer-Verlag)

    Google Scholar 

  10. Campbell, J., Pierluissi, J. and Kovacs, K. (1981). Pancreatic islet ultrastructure, serum and pancreatic immunoreactive insulin in somatotrophic and metasomatotrophic diabetes in dogs. J. Submicrosc. Cytol., 13, 599–608.

    PubMed  CAS  Google Scholar 

  11. Kovács, K., Horvath, E., Asa, S. L., Murray, D., Singer, W. and Reddy, S. S. (1986). Microscopic peliosis of pancreatic islets in a woman with MEN-1 Syndrome. Arch. Pathol. Lab. Med., 110, 607–610.

    PubMed  Google Scholar 

  12. Beliles, R. P. (1971). The subchronic toxicity of 5-benzyl-11-[4- (AAmethyl-piperidylene)]-5,6-dihydromorphanthridine hydrogen maleate. Toxicol. Appl. Pharmacol., 18, 451–56.

    Article  PubMed  CAS  Google Scholar 

  13. Gräf, R. (1981). Immunocytochemical detection of anti-ACTH reactivity in pancreatic islet cells of normal and steroid diabetic rats. Histochemistry, 73, 233–238.

    Article  PubMed  Google Scholar 

  14. Rozman, K., Pereira, D. and latropoulos, M. J. (1986). Histopathology of interscapular brown adipose tissue, thyroid and pancreas in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Toxicol. Appl. Pharmacol., 82, 551–559.

    Article  PubMed  CAS  Google Scholar 

  15. Mori, T., Nagasawa, H., Namiki, H. and Niki, K. (1986). Development of pancreatic hyperplasia in female SHN mice receiving ectopic pituitary isografts. J. Natl. Cancer Inst. 76, 1193–1197.

    PubMed  CAS  Google Scholar 

  16. Rakieten, N., Gordon, B. S., Beaty, A., Cooney, D. A., Davis, R. D. and Schein, P. S. (1971). Pancreatic islet cell tumours produced by the combined action of streptozotocin and nicotinamide. Proc. Soc. Exp. Biol. Med., 137, 280–283.

    PubMed  CAS  Google Scholar 

  17. Yamagami, T., Miwa, A., Takasaw, S., Yamamoto, H. and Okamoto, H. (1985). Induction of rat pancreatic (β-cell tumours by the combined administration of streptozotocin and alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res., 45 , 1845–1849.

    PubMed  CAS  Google Scholar 

  18. Schoental, R., Fowler, M. E. and Coady, A. (1970). Islet cell tumors of the pancreas found in rats given pyrrolidine alkaloids. Cancer Res., 30, 2127–2131.

    PubMed  CAS  Google Scholar 

  19. Like, A. A. and Chick, W. L. (1974). Pancreatic beta cell replication induced by glucocorticoids in subhuman primates. Am. J. Pathol., 75, 329–341.

    PubMed  CAS  Google Scholar 

  20. Roe, F. J. C. and Bar, A. (1985). Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption. Human Toxicol., 4, 27–52.

    Article  CAS  Google Scholar 

  21. Novak, R., Wilimas, J. and Johnson, W. (1979). Hypertrophy and hyperplasia of islet of Langerhans associated with androgen therapy. Arch. Pathol. Lab. Med., 103, 483–485.

    PubMed  CAS  Google Scholar 

  22. Sale, G. E. and Lemer, K. G. (1977). Multiple tumours after androgen therapy. Arch. Pathol. Lab. Med., 101, 600–603.

    PubMed  CAS  Google Scholar 

  23. Meuris, S., Verloes, A. and Robyn, C. (1983). Immunocytochemical localisation of prolactin-like immunoreactivity in rat pancreatic islets. Endocrinology, 112, 2221–2223.

    Article  PubMed  CAS  Google Scholar 

  24. Orci, L., Beatens, D., Rufener, C., Amherdt, M., Ravazzola, M., Studer, P., Malaisse-Lague, F. and Linger, R. H. (1976). Hypertrophy and hyperplasia of somatostatin-containing D- cells in diabetes. Proc. Natl. Acad. Sci. USA, 73, 1338–1342.

    Article  PubMed  CAS  Google Scholar 

  25. Tandler, B., Hutter, R. V. P. and Erlandson, R. A. (1970). Ultrastructure of oncocytoma of the parotid gland. Lab. Invest., 23, 567–580.

    PubMed  CAS  Google Scholar 

  26. O’Leary, T. J., Costa, J. and Roth, J. (1982). Oncocytic nodules of the pancreas. Lab. Invest., 46, 63A.

    Google Scholar 

Thyroid

  1. Stevens, J. T. (1985). Effect of chemicals on the thyroid gland. In Thomas, J. A., Korach, K. S. and McLachlan, J. A. (eds.) Endocrine Toxicology, pp. 135–147. (New York: Raven)

    Google Scholar 

  2. Lumb, G. D. and Rust, J. H. (1985). The pathologic response of the liver and thyroid of the rat to potassium prorenoate (SC — 23992). Toxicol. Pathol. 13, 315–324.

    Article  PubMed  CAS  Google Scholar 

  3. Heath, J. E. and Littlefield, N. A. (1984). Morphological effects of subchronic oral sulfamethazine administration on Fischer 344 rats and B6C3Fi mice. Toxicol. Pathol., 12, 3–9.

    Article  PubMed  CAS  Google Scholar 

  4. Collins, W. T., Capen, C. C Kasza, L., Carter, C. and Dailey, R. E. (1977). Effect of polychlorinated biphenyl (PCB) on the thyroid gland of rats. Am. J. Pathol., 89, 119–130.

    PubMed  CAS  Google Scholar 

  5. Takayama, S., Aihara, K., Onodera, T. and Akimoto, T. (1986). Antithyroid effects on propylthiouracil and sulfamonomethox- ine in rats and monkeys. Toxicol. Appl. Pharmacol., 82, 191–199.

    Article  PubMed  CAS  Google Scholar 

  6. Lumb, G., Newberne, P., Rust, J. H. and Wagner, B. (1978). Effects in animals of chronic administration of spironolactone — a review. J. Environ. Pathol. Toxicol., 1, 641–660.

    PubMed  CAS  Google Scholar 

  7. Todd, G. C. (1986). Induction and reversibility of thyroid proliferative changes in rats given an antithyroid compound. Vet. Pathol., 23, 110–117.

    Article  PubMed  CAS  Google Scholar 

  8. Mahmoud, I., Colin, I., Many, M-C., Denef, J-F. (1986). Direct toxic effect of iodine in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation. Exp. Mol. Pathol., 44, 259–271.

    Article  PubMed  CAS  Google Scholar 

  9. Tachiwaki, O. and Wollman, S. H. (1982). Shedding of dense cell fragments into the follicular lumen early in involution of the hyperplastic thyroid gland. Lab. Invest., 47, 91–98.

    PubMed  CAS  Google Scholar 

  10. Kallfelz, F. A. (1977). Thyroid function in the dog. Vet. Clin. N. Am., 7, 497–512.

    CAS  Google Scholar 

  11. Jones, A. L. and Armstrong, D. T. (1965). Increased cholesterol biosynthesis following phenobarbital induced hypertrophy of agranular endoplasmic reticulum in liver. Proc. Soc. Exp. Biol. Med., 119, 1136–1139.

    PubMed  CAS  Google Scholar 

  12. Tajima, K., Miyagawa, J-L., Nakajima, H., Shimizu, M., Katayama, S., Mashita, K. and Tarui, S. (1985). Morphological and biochemical studies on minocycline-induced black thyroid in rats. Toxicol. Appl. Pharmacol., 81, 393–400.

    Article  PubMed  CAS  Google Scholar 

  13. Ward, J. M., Stinson, S. F., Hardisty, J. F., Cockrell, B. Y. and Hayden, D. W. (1979). Neoplasms and pigmentation of thyroid glands in F344 rats exposed to 2,4-diaminoanisole sulfate, a fair dye component. J. Natl. Cancer Inst., 62, 1067–1073.

    PubMed  CAS  Google Scholar 

  14. Evarts, R. P. and Brown, C. A. (1981). 2,4-diaminoanisole — induced thyroid pigmentation in rats inhibited by m-phenylenediamine. Toxicol. Lett. 8, 257–264.

    Article  PubMed  CAS  Google Scholar 

  15. Benathon, M., Lemarchand-Béraud, Th., Gautier, A. and Gardiol, D. (1983). Abnormal iodoprotein distribution and resistance to proteolysis in Gunn rat black thyroid. Virchows Arch. B: Zellpathol., 44, 323–336.

    Article  Google Scholar 

  16. Vereczkey, L. (1985). Pharmacokinetics and metabolism of vincamine and related compounds. Eur. J. Drug Metab. Pharm., 10, 89–103.

    Article  CAS  Google Scholar 

  17. Gordon, G., Sparano, B. M., Kramer, A. W., Kelly, R. G. and latropoulos, M.J. (1984). Thyroid gland pigmentation and minocycline therapy. Am. J. Pathol., 117, 98–109.

    PubMed  CAS  Google Scholar 

  18. Renber, M. D. and Glover, E. L. (1976). Role of age and sex in chronic thyroiditis in rats fed 3’-methyl-4-dimethylaminoazo-benzene. Vet. Pathol., 13, 295–302.

    Google Scholar 

  19. Kitchen, D. N., Todd, G. C., Meyers, D. B. and Paget, C. (1979). Rat lymphocytic thyroiditis associated with ingestion of an immunosuppressive compound. Vet. Pathol., 16, 722–729.

    PubMed  CAS  Google Scholar 

Parathyroid

  1. Young, D. M., Olson, H. M., Prieur, D. J., Cooney, D. A. and Reagan, R. L. (1973). Clinocopathologic and ultrastructural studies of L-asparaginase-induced hypocalcaemia in rabbits. Lab. Invest., 29, 374–386.

    PubMed  CAS  Google Scholar 

  2. Atwal, O. S. and Pemsingh, R. S. (1981). Morphology of microvascular changes and endothelial regeneration in experimental ozone-induced parathyroiditis. Am. J. Pathol., 102, 297–307.

    PubMed  CAS  Google Scholar 

Pituitary

  1. Dada, M. O., Campbell, G. T. and Blake, C. A. (1984). Pars distalis cell quantification in normal adult male and female rats. J. Endocrinol., 101, 87–94.

    Article  PubMed  CAS  Google Scholar 

  2. Kovács, K., Carroll, R. and Tapp, E. (1966). The pathogenesis of hexadimethrine necrosis of the pituitary and adrenal. Arzneim- Forsch., 16, 516–519.

    Google Scholar 

  3. Capen, C. C. (1983). Functional pathologic interrelationships of the pituitary gland and the hypothalamus. In Jones, T. C., Mohr, U. and Hunt R. D. (eds.) Endocrine System. Monographs on Pathology of Laboratory Animals, pp. 101–120. (Berlin and Heidelberg: Springer-Verlag)

    Google Scholar 

  4. Tsuda, H. (1983). Goiter, adenoma and carcinoma of the thyroid induced by amitrole and ethylenthiourea, rat. In Jones, T. C., Mohr, U. and Hunt, R. D. (eds.) Endocrine System. Monographs on Pathology of Laboratory Animals, pp. 204–211. (Berlin and Heidelberg: Springer-Verlag)

    Google Scholar 

  5. Osamura, R. Y. and Takayama, S. (1983). Histochemical identification of hormones in pituitary tumors, rat. In Jones, T. C., Mohr, U. and Hunt, R. D. (eds.) Endocrine System. Monographs on Pathology of Laboratory Animals, pp. 130–134. (Berlin and Heidelberg: Springer-Verlag)

    Google Scholar 

  6. Evarts, R. P. and Brown, C. A. (1981). 2,4-diaminoanisole-induced thyroid pigmentation in rats inhibited by m-phenylene- diamine. Toxicol. Lett., 8, 257–264.

    Article  PubMed  CAS  Google Scholar 

  7. Farquahar, M. G. (1969). Lysosome function in regulating secretion: disposal of secretory granules in cells of the anterior pituitary gland. In Dingle, J. T. and Fell, H. B. (eds.) Lysosomes in Biology and Pathology, pp. 462–482. (Amsterdam: North Holland)

    Google Scholar 

  8. Landolt, A. M. (1979). Pituitary adenomas. J. Histochem. Cyto- chem., 27, 1395–1397.

    Article  CAS  Google Scholar 

  9. El Etreby, M. F. (1981). Practical applications of immunocytoch- emistry of the pharmacology and toxicology of the endocrine system. Histochem. J., 13, 821–837.

    Article  PubMed  Google Scholar 

  10. Dakshinamurti, K., Paulose, C. S. and Vriend, J. (1986). Hypothyroidism of hypothalamic origin in pyridoxine-deficient rats. J. Endocrinol., 109, 345–349.

    Article  PubMed  CAS  Google Scholar 

  11. Lloyd, R. V. (1983). Estrogen-induced hyperplasia and neoplasia in the rat anterior pituitary gland. Am. J. Pathol., 113, 198–206.

    PubMed  CAS  Google Scholar 

  12. El Etreby, M. F., Gräf, K. J., Günzel, P. and Neumann, F. (1979). Evaluation of effects of sexual steroids on the hypothalamic pituitary system of animals and man. Arch. Toxicol., Suppl. 2, 11–39.

    Google Scholar 

  13. Roe, F. J. C. and Bär, A. (1985). Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption. Human Toxicol., 4, 27–52.

    Article  CAS  Google Scholar 

  14. Horowski, R. and Gräf, K. J. (1979). Neuroendocrine effects of neurosychotrophic drugs and their possible influence on toxic reactions in animals and man — the role of dopamine-prolactin system. Arch. Toxicol., Suppl. 2, 93–104.

    Google Scholar 

  15. Meites, J. (1979). Role of neuroendocrine system in regulation of mammary tumors in different species. Arch. Toxicol. Suppl. 2, 47–58.

    PubMed  Google Scholar 

  16. Saunders, S. L., Reifel, C. W. and Shin, S. H. (1983). Ultrastructural changes rapidly induced by somatostatin may inhibit prolactin release in estrogen-primed rat adenohypophysis. Cell Tiss. Res., 232, 21–34.

    Article  CAS  Google Scholar 

  17. Gooren, L. J. G., Harmsen-Louman, W. and van Kessel, H. (1984). Somatostatin inhibits prolactin release from the lactotrophs primed with oestrogen and cyproterone acetate in man. J. Endocrinol., 103, 333–335.

    Article  PubMed  CAS  Google Scholar 

  18. Haggi, E. S., Torres, A. I., Maldonado, C. A. and Aoki, A. (1986). Regression of redundant lactotrophs in rat pituitary gland after cessation of lactation. J. Endocrinol., 111, 367–373.

    Article  PubMed  CAS  Google Scholar 

  19. Saluja, P. G., Hamilton, J. M., Thody, A. J., Ismail, A. A. and Knowles, J. (1979). Ultrastructure of intermediate lobe of the pituitary and melanocyte-stimulating hormone secretion in oestrogen-induced kidney tumors in male hamsters. Arch. Toxicol., Suppl. 2, 41–45.

    PubMed  Google Scholar 

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© 1987 C. Gopinath, D. E. Prentice and D. J. Lewis

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Gopinath, C., Prentice, D.E., Lewis, D.J. (1987). The Endocrine Glands. In: Atlas of Experimental Toxicological Pathology. Current Histopathology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3189-3_8

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