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The Eye and Ear

  • Chapter
Atlas of Experimental Toxicological Pathology

Part of the book series: Current Histopathology ((CUHI,volume 13))

Abstract

Adverse ocular side-effects in man, due to therapeutic agents, have received considerable attention and are widely reported1−4. The profusion of reports may give a disproportionate view of selective organ toxicity. In practice histopathologically detectable changes in the eyes are relatively rare in animal safety evaluation studies, although there is evidence of species variation and susceptibility, probably resulting from differences in metabolism4.

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Author information

Authors and Affiliations

  1. Huntingdon Research Centre, Huntingdon, UK

    C. Gopinath (Director of Pathology)

  2. Pharmaceutical Division, Sandoz Ltd, Basle, Switzerland

    D. E. Prentice (Head of Pathology Group, Deputy Head of Toxicology Department)

  3. Huntingdon Research Centre, Huntingdon, UK

    D. J. Lewis (Deputy Head of Pathology)

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  1. C. Gopinath
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  2. D. E. Prentice
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  3. D. J. Lewis
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© 1987 C. Gopinath, D. E. Prentice and D. J. Lewis

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Gopinath, C., Prentice, D.E., Lewis, D.J. (1987). The Eye and Ear. In: Atlas of Experimental Toxicological Pathology. Current Histopathology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3189-3_11

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  • DOI: https://doi.org/10.1007/978-94-009-3189-3_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7930-3

  • Online ISBN: 978-94-009-3189-3

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