Copper therapy of inflammatory disorders: efficacy and biodistribution of topically applied copper complexes

  • S. J. Beveridge
Part of the Inflammation and Drug Therapy Series book series (IDTH, volume 4)


The use of copper devices, especially bracelets, for anti-inflammatory/anti-arthritic purposes goes back into folk-lore. Yet it is only of recent times that any serious attempt has been made to assess the validity or otherwise of the hypothesis that metallic copper can generate or promote anti-inflammatory activity in vivo. In providing some evidence for the probable therapeutic value of the copper bracelet, Walker and Keats1 suggested that the components of sweat (especially amino acids) may act as cupriphores. Subsequently, the dissolution of copper in sweat was reported by Walker and Griffin2. Further evidence for the hypothesis was provided when Walker et al. 3 observed that 64Cu-labelled bis(glycinato) copper(II) could permeate intact cat skin. In addition, the perfusion of human skin by copper(II) acetate has been reported by Odintsova4. Some evidence for the reactivity of metallic copper may be adduced from the observation that the crystalline solid bis(glycinato) cop-per(II) monohydrate can be isolated from an aerated aqueous solution of glycine containing metallic copper5.


Salicylic Acid Copper Complex Metallic Copper Niflumic Acid 64Cu Radioactivity 
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  1. 1.
    Walker, WR and Keats, DM (1976). An investigation of the therapeutic value of the Copper ‘Bracelet’; Dermal assimilation of copper in arthritic/rheumatoid conditions Agents Actions, 6, 454–459PubMedCrossRefGoogle Scholar
  2. 2.
    Walker, WR and Griffin, BJ (1976). The solubility of copper in human sweat. Search, 7, 100–101Google Scholar
  3. 3.
    Walker, WR, Reeves, RR, Brosnan, M and Coleman, GD (1977). Perfusion of intact skin by a saline solution of bis(glycinato) copper(II). Bioinorg Chem, 7, 271–276PubMedCrossRefGoogle Scholar
  4. 4.
    Odintsova, NA (1978). Permeability of human skin to potassium and copper ions and their ultrastructural localization. Chem Abs, 89, 360, Abs No 126707Google Scholar
  5. 5.
    Beveridge, SJ and Walker, WR (1980). Formation of hydroxo-bridged copper(II) complexes by aeration of metallic copper. Aust J Chem, 33, 2331–2335CrossRefGoogle Scholar
  6. 6.
    Bekemeier, H (ed) (1977). 100 Years of the Salicylic Acid as an Anti-rheumatic Drug, (Martin-Luther Universitat Halle-Wittenberg, Wissenschaftliche Beitrage), p.623Google Scholar
  7. 7.
    Chenoweth, MB (1956). Chelation as a mechanism of pharmacological action. Pharmocol Rev, 8,57–87Google Scholar
  8. 8.
    Schubert, J (1966). Chelation in medicine. Sci Am, 214, (5), 40–50PubMedCrossRefGoogle Scholar
  9. 9.
    Schubert, J (1960). Chelation in medicine. In Seven, MJ and Johnson, LA (eds). Metal Binding in Medicine, (Philadelphia: Lippincott), p.325Google Scholar
  10. 10.
    Walker, WR, Beveridge, SJ and Whitehouse, MW (1980). Anti-inflammatory activity of a dermally applied copper salicylate preparation (Alcusal®). Agents Actions, 10, 38–47PubMedCrossRefGoogle Scholar
  11. 11.
    Beveridge, SJ, Walker, WR and Whitehouse MW (1980). Anti-inflammatory activity of copper salicylates applied to rats percutaneously in dimethyl sulphoxide with glycerol. J Pharm Phrmacol, 32, 425–427CrossRefGoogle Scholar
  12. 12.
    Beveridge, SJ, Whitehouse, MW and Walker, WR (1982). Lipophilic copper (II) formulations: some correlations between their composition and anti-inflammatory/antiarthritic activity when applied to the skin of rats. Agents Actions, 12, 225–231PubMedCrossRefGoogle Scholar
  13. 13.
    Bergqvist, U and Sundbom, M (1978). Copper-Health and Hazard. (Sweden: University of Stockholm Press)Google Scholar
  14. 14.
    Beveridge, SJ, Boettcher, B, Walker, WR and Whitehouse, MW (1984). Biodistribution of 64Cu in rats after topical application of two lipophilic anti-inflammatory Cu(II) formulations. Agents Actions, 14, 291–295PubMedCrossRefGoogle Scholar
  15. 15.
    Beveridge, SJ, Garrett, IR, Whitehouse, MW, Vernon-Roberts, B and Brooks, PM (1985). Biodistribution of 64Cu in inflamed rats following administration of two antiinflammatory copper complexes. Agents Actions, 17, 104–111PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • S. J. Beveridge
    • 1
  1. 1.Department of Applied SciencesHunter Institute of Higher EducationWaratahAustralia

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