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Hypercalciuria

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Calculus Disease

Part of the book series: New Clinical Applications ((NCNG,volume 2))

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Abstract

The majority of patients who form stones within the urinary tract have an associated metabolic disorder. A relationship between the increased excretion of calcium in the urine in patients with renal and ureteric calculi was first noted by Flocks1,2 but it was Albright3 who, in 1953, first coined the term ‘idiopathic hypercalciuria’, suggesting that the condition might have a tubular origin and drawing attention to the hypophosphataemia which is often present. A few years later, Henneman et al.4 demonstrated high calcium absorption, and, subsequently, Jackson and Dancaster5 suggested that this hyper-absorpiion was an adaptation to the increased urinary calcium loss. No cause can be identified in nearly all normocalcaemic hypercalciuric patienss and an autosomal dominant mode of inheritance has been suggested6. The prevalence of hypercalciuria is approximately 5% in otherwise normal adults, and, in 95% of these subjects, hypercalciuria is silent and not associated with stone formation.

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Authors
  1. V. L. Sharman
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Editors and Affiliations

  1. University of Aberdeen and Honorary Consultant Physician/Nephrologist to the Grampian Health Board, UK

    Graeme R. D. Catto MD, FRCP, FRCP(G) (Reader in Medicine, Harkness Fellow) (Reader in Medicine, Harkness Fellow)

  2. Harvard Medical School and the Peter Bent Brigham Hospital, Boston, USA

    Graeme R. D. Catto MD, FRCP, FRCP(G) (Reader in Medicine, Harkness Fellow) (Reader in Medicine, Harkness Fellow)

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© 1988 Kluwer Academic Publishers

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Sharman, V.L. (1988). Hypercalciuria. In: Catto, G.R.D. (eds) Calculus Disease. New Clinical Applications, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2617-2_2

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  • DOI: https://doi.org/10.1007/978-94-009-2617-2_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7681-4

  • Online ISBN: 978-94-009-2617-2

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