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The Chronobiologic Pilot Study with Special Reference to Cancer Research is Chronobiology or, rather, its Neglect Wasteful?

  • Chapter
Cancer Management in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 9))

Abstract

It is customary in biologic and, in particular, in medical research to do a pilot study first. Statements such as ‘... undertook the pilot study to evaluate the methodology for conducting a main study. The pilot study was not designed to yield definitive results, but the figures are suggestive’ (22) and often found in the medical literature. Such pilots are indispensable in order to ascertain that a given chemical or biologic method ‘works’. ‘Work’ may also mean that an anticipated effect is found. If timing enters a pilot protocol, it is usually in the form of a suggestion that the study be carried out at one convenient timepoint. If the pilot is encouraging, in cancer or other research, carried out by testing, for instance, a new drug, a ‘definitive’ approach is practiced. A new treatment is compared with an old one. Usually, the therapeutic arms are specified as to dose, but hardly ever with respect to circadian and other rhythm stage. A chronobiologic assessment of drug effect is also not usually considered. If the ‘pilot’ is negative, the approach is no longer pursued.

This review extends the scope of an earlier paper prepared on the chronobiologic pilot by Halberg (1987 and partly unpublished), amplifying on studies in Halberg et al. (66) and adds oncologic focus to this and other such pilot designs, including a jointly developed approach by triangulation, so named by the senior author (GC).

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Authors
  1. Germaine Cornélissen
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  2. Franz Halberg
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Editors and Affiliations

  1. Department of Radiotherapy, Howard University College of Medicine and Howard University Hospital, 2401 Georgia Ave., Washington D.C., 20060, USA

    Alfred L. Goldson M.D.

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© 1989 Kluwer Academic Publishers, Dordrecht

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Cornélissen, G., Halberg, F. (1989). The Chronobiologic Pilot Study with Special Reference to Cancer Research is Chronobiology or, rather, its Neglect Wasteful?. In: Goldson, A.L. (eds) Cancer Management in Man. Cancer Growth and Progression, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2536-6_9

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  • DOI: https://doi.org/10.1007/978-94-009-2536-6_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7646-3

  • Online ISBN: 978-94-009-2536-6

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