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Influence of Tumor Development on the Host pp 28–34Cite as

Ion Deregulation, Cell Injury and Tumor Promotion

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 3))

Abstract

The purpose of this paper is to critically review and analyze the literature concerning the role of cellular ion deregulation in growth and differentiation specifically as it relates to tumor promotion. It has become evident in recent years that ion deregulation plays a significant role in cell division and cell death; concurrently, studies have been performed suggesting significant differences in neoplastic versus normal cells and in the effects of tumor promoters such as phorbol esters. Although many regulatory processes including ions are involved, the focus of this review will be limited to the roles of sodium, calcium and proton deregulation. We will also present our hypothesis correlating such ionic changes with a variety of cell effects and responses related to tumorigenesis in which we have developed a construct of the interaction between ion regulation, cell division, and cell differentiation. Implicit in this hypothesis is the intimate relationship between acute toxic cell injury, normal regeneration, and neoplasia; therefore, it has important regulations for nongenotoxic mechanisms of neoplasia including tumor promotion and enhancement.

Supported by NIH grants AM15440 and NOl-CP-15738. This is contribution No. 2217 from the Cellular Pathobiology Laboratory.

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Authors
  1. Benjamin F. Trump
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  2. Irene K. Berezesky
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  3. Kookmin M. Kim
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Editor information

Editors and Affiliations

  1. Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Lance A. Liotta

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© 1989 Kluwer Academic Publishers, Dordrecht

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Trump, B.F., Berezesky, I.K., Kim, K.M. (1989). Ion Deregulation, Cell Injury and Tumor Promotion. In: Liotta, L.A. (eds) Influence of Tumor Development on the Host. Cancer Growth and Progression, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2528-1_4

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  • DOI: https://doi.org/10.1007/978-94-009-2528-1_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7642-5

  • Online ISBN: 978-94-009-2528-1

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