Abstract
Seasonal or more precisely, “circannual” rhythms (23) have been reported for neoplastic processes in various contexts, both in the living organism and in isolated organ systems (29). In human patients, for example, specific peaks have been noted for certain months of the year — and as one might expect, questioned as well — over several decades (10, 21, 27, 29, 34, 44, 49). Moreover, the partial resemblance to cyclic trends of infections or vector-borne diseases may have helped to keep some of the simpler models of cancer causation alive. More recently research has focused on associated circannual, biological and hormonal parameters, hematological variables, receptor concentration, immune responses, and many investigations bearing on bioavailability (9, 16, 29, 31–33, 36, 46, 48, 51).
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Empirical result and beginnings of a theoretical framework. Professor Dr. Dr. E.H. Krokowski died November 5, 1985. The editorial decision was made to leave the chapter essentially unchanged.
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Krokowski, E.H., Wendt, H.W., Homyak, P.A. (1989). Season of Operation and Differential Long-Term Progression: Clinical, Statistical, and Psychological Issues. In: Weisburger, E.K. (eds) Mechanisms of Carcinogenesis. Cancer Growth and Progression, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2526-7_19
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