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Induction of Ovulation with the Combination of LHRH Analog in a Short Protocol and Exogenous Gonadotropins

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GnRH Analogues in Cancer and Human Reproduction

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Abstract

A better control of ovarian hyperstimulation is an important element in improving results of in vitro fertilization (IVF). Many existing therapeutic protocols utilise substances like clomiphene citrate (CC), human gonadotropins (HMG) or GnRH. Because of the overall satisfactory results, the gonadotropins alone or associated with clomiphene citrate have generally been used in the induction of ovulation. However, there are two major drawbacks in these regimens. A proportion of patients show a poor reproductive response due to poor follicular development. The presence of frequent spontaneous LH surges and even elevated LH levels during the late follicular phase before the induction of ovulation by HCG influences the results. To avoid these endogenous pituitary interferences, the production of reversible medical hypophysectomy, by use of GnRH analogs, has been advocated.

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Author information

Authors and Affiliations

  1. IVF Department, CHU Nantes, Nantes Cedex 01, 44035, France

    P. Barriere, P. Lopes & B. Charbonnel

Authors
  1. P. Barriere
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  2. P. Lopes
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  3. B. Charbonnel
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Editor information

Editors and Affiliations

  1. Institute of Biological Sciences, Syntex Research, Palo Alto, CA, 94304, USA

    Brian H. Vickery

  2. Institute of Endocrinology, Sheba Medical Center, Bar Ilan University, Remat Gan, 52621, Israel

    Bruno Lunenfeld

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© 1990 Springer Science+Business Media Dordrecht

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Barriere, P., Lopes, P., Charbonnel, B. (1990). Induction of Ovulation with the Combination of LHRH Analog in a Short Protocol and Exogenous Gonadotropins. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2169-6_15

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  • DOI: https://doi.org/10.1007/978-94-009-2169-6_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7474-2

  • Online ISBN: 978-94-009-2169-6

  • eBook Packages: Springer Book Archive

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