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Biological Applications of 51V NMR Spectroscopy

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Vanadium in Biological Systems

Abstract

Application of 51V NMR to genuine biological systems has developed only during the last few years and consequently is still restricted to a small number of examples, viz. vanadate binding to serum albumin and apo-transferrin, the nature of the coordination environment of vanadium in vanadate-dependent halo-peroxidases from knobbed wrack (a marine brown alga), and the interaction of vanadate with several enzymes involved in phosphorylation reactions (phosphoglycerate mutase, alkaline phosphatase, ribonuclease A and ribonuclease T1). The main problem with large biological molecules arises from the quadrupole moment of 51V which, in most cases so far investigated, induces very broad resonance lines (see below). On the other hand, 51V NMR has frequently and successfully been employed to investigate the formation of complexes between vanadate, VO3+ or VO2 + and small organic molecules, which are part of or closely related to large biological matrices, such as oligopeptides, hydroxycarboxylic acids, phenols, saccharides, functionalized amines, nucleotides and nucleosides. Studies of these systems have revealed insight not only into the ligand behavior of biogenic and bio-mimetic molecules, but also into thermodynamic (and kinetic) properties of simple and complex systems underlying chemical exchange. Examples are the determination of formation constants for the weak complexes formed between vanadate and dipeptides, or esters and mixed anhydides of the hypothetical orthovanadium acid.

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Authors and Affiliations

  1. Institute of Inorganic Chemistry, The University, Martin Luther King Platz 6, D-2 Hamburg 13, Germany

    Dieter Rehder

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  1. Dieter Rehder
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Editors and Affiliations

  1. Department of Chemistry, University of New Hampshire, USA

    N. Dennis Chasteen

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© 1990 Kluwer Academic Publishers

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Rehder, D. (1990). Biological Applications of 51V NMR Spectroscopy. In: Chasteen, N.D. (eds) Vanadium in Biological Systems. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2023-1_10

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  • DOI: https://doi.org/10.1007/978-94-009-2023-1_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7407-0

  • Online ISBN: 978-94-009-2023-1

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