Abstract
Extensive mutation studies of the glucocorticoid receptor (GR) and its target cis elements (GRE, 1) revealed a number of expected as well as some unexpected features of the molecular interactions underlying receptor mediated transcriptional control. We can show that constitutive GR fragments can work as promoter as well as “pure” enhancer factors. Furthermore, we propose an additional DNA target-discrimination role for the hormone binding domain of the GR.
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© 1990 Kluwer Academic Publishers
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Wieland, S., Galli, I., Schatt, M., Severne, Y., Rusconi, S. (1990). Genetic and Biochemical Analysis of a Steroid Receptor. In: Alexis, M.N., Sekeris, C.E. (eds) Activation of Hormone and Growth Factor Receptors. NATO ASI Series, vol 295. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1936-5_18
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DOI: https://doi.org/10.1007/978-94-009-1936-5_18
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7364-6
Online ISBN: 978-94-009-1936-5
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