Abstract
One of the striking features of hormonal regulation is the specifity of the response. One element contributing to this specificity is the ligand itself. Since the sequence of the receptor proteins is known by cloning of their cDNAs it is clear that each steroid hormone binds to a different polypeptide (Evans, 1988). Comparison of different parts of the receptor have shown that the most conserved part of the protein is the region interacting with the DNA (the hormone response element, HRE) whereas the part forming the hormone binding domain is less well conserved but still shows considerable homology.
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Schmid, W., Strähle, U., Mestril, R., Ankenbauer, W., Schütz, G. (1990). Steroid Response Elements: Composite Structure and Definition of a Minimal Element. In: Alexis, M.N., Sekeris, C.E. (eds) Activation of Hormone and Growth Factor Receptors. NATO ASI Series, vol 295. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1936-5_13
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DOI: https://doi.org/10.1007/978-94-009-1936-5_13
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