Abstract
Hormone and growth factor receptors elicit changes in gene expression which regulate cellular homeostasis, proliferation and differentiation. Many oncogenes code for aberrant hormone and growth factor receptors (e.g. v-erbA and v-erbB). The deregulated action of these products interferes with normal signal transduction for cellular proliferation and differentiation, thus leading to cellular transformation. In this context, receptor-mediated transcriptional effects are directly related to the molecular mechanisms underlying oncogenic transformation.
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© 1990 Kluwer Academic Publishers
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Alexis, M.N., Sekeris, C.E. (1990). “Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences”: A Record of the Meeting. In: Alexis, M.N., Sekeris, C.E. (eds) Activation of Hormone and Growth Factor Receptors. NATO ASI Series, vol 295. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1936-5_1
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DOI: https://doi.org/10.1007/978-94-009-1936-5_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7364-6
Online ISBN: 978-94-009-1936-5
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