Pathophysiologic mechanisms of aluminum toxicity: Aluminum-induced bone disease

  • William G. Goodman
Part of the Developments in Nephrology book series (DINE, volume 26)


The accumulation of aluminum in tissues has been implicated in the pathogenesis of several clinical disorders of the musculoskeletal, central nervous, and hematologic systems [1–4]. Early clinical reports suggested that aluminum deposition in brain was related to the development of a progressive and lethal encephalopathy in patients receiving maintenance hemodialysis. Many patients with the syndrome of dialysis encephalopathy, or dialysis dementia, also exhibited clinical manifestations of a severe form of osteomalacia characterized by recurrent fractures and progressive muscle weakness [5,6]. This disorder was usually refractory to treatment with active vitamin D sterols, and several clinical and biochemical features distinguished it from other types of renal osteodystrophy [7–9]. Subsequent investigations documented that patients with concurrent manifestations of dialysis- associated osteomalacia and encephalopathy had extensive deposits of aluminum in bone [10, 11]. Water that contained aluminum and that was used for the preparation of hemodialysis solutions was the predominant source of aluminum loading in these patients [2, 12, 13].


Bone Formation Renal Osteodystrophy Mineralization Front Aluminum Deposition Aluminum Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • William G. Goodman

There are no affiliations available

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