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Aluminium determination in biological samples

  • Caroline D. Hewitt
  • Michael R. Wills
  • John Savory
Chapter
Part of the Developments in Nephrology book series (DINE, volume 26)

Abstract

Clinical and other biochemical studies of trace metals depend upon accurate and precise methods of analysis. A review of the history of aluminium-related diseases [1] indicates that it was the measurement of aluminium in brain and other tissues that led to the proposal that this metal was a causative agent responsible for the condition now recognised as dialysis encephalopathy [2]. An early study showed that the bones of Newcastle dialysis patients contained both an excess of aluminium and an excess of fluoride compared with patients who had been dialysed in other treatment centres [3]. Likewise, it was the discovery of high aluminium concentrations in the water supplies of geographical areas coincident with the dialysis centres with the greatest incidence of dementia and dialysis osteodystrophy that provided crucial evidence in identifying the major source of aluminium exposure for haemodialysis patients [4].

Keywords

Graphite Furnace Atomic Absorption Spectrometry Graphite Tube Electrothermal Atomic Absorption Spectrometry Aluminium Exposure Transiliac Bone Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Caroline D. Hewitt
  • Michael R. Wills
  • John Savory

There are no affiliations available

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