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The metabolism of aluminum

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Aluminum and renal failure

Part of the book series: Developments in Nephrology ((DINE,volume 26))

Abstract

The knowledge of the aluminum metabolism has been acquired slowly over the years. This is mainly due to the lack of radioactive aluminum isotopes suitable for metabolic studies. Radioactive aluminum isotopes show either very short (28 Al: 2.3 min) or very long (26Al: 7.4 x 105 years) half-lifes. The only non-radioactive aluminum isotope is the naturally occurring 27Al.

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References

  1. Alfrey AC, LeGendre GR, Kaehny WD, 1976: The dialysis encephalopathy syndrome: possible aluminum intoxication. N Engl J Med 294: 184.

    Article  PubMed  CAS  Google Scholar 

  2. Alfrey AC, 1980a: Aluminium metabolism in uremia. Neurotoxicoly 1: 43.

    CAS  Google Scholar 

  3. Alfrey AC, Hegg A, Craswell P, 1980b: Metabolism and toxicity of aluminum in renal failure. Am J Clin Nutr 33: 1509.

    PubMed  CAS  Google Scholar 

  4. Alfrey AC, 1985: The case against aluminum affecting parathyroid function. Am J Kidney Dis 6: 309.

    PubMed  CAS  Google Scholar 

  5. Alfrey AC, 1986: Aluminum metabolism. Kidney Int 29 (suppl 18): S8.

    CAS  Google Scholar 

  6. Andersen K-J, Nordgaard K, Julshamn K, Schjoensby H, 1979: Increased serum aluminum in patients with jaundice. N Engl of Med 30s: 728.

    Google Scholar 

  7. Bakir AS, Hryhorczuk DO, Berman E, Dunea G, 1986: Acute fatal hyperaluminemic encephalopathy in undialyzed and recently dialyzed uremic patients. Trans Am Soc Artif Intern Organs 32: 171.

    CAS  Google Scholar 

  8. Burnatowska-Hledin MA, Mayor GH, Lau K, 1985a: Renal handling of aluminum in the rat: clearance and micropuncture studies. Am J Physiol 249: F192.

    PubMed  CAS  Google Scholar 

  9. Burnatowska-Hledin MA, Klein AM, Mayor GH, 1985b: Effect of aluminum on the renal handling of phosphate in the rat. Am J Physiol 248: F64.

    PubMed  CAS  Google Scholar 

  10. Burnatowska-Hledin MA, Doyle TM, Eadie MJ, Mayor GH, 1986: 1, 25-dihydroxyvitamin D3 increases serum and tissue accumulation of aluminum in rats. J Lab Clin Med 108: 96.

    Google Scholar 

  11. Cochran M, Patterson D, Neoh S, Stevens B, Mazzachi R, 1985: Binding of Al by protein in plasma of patients on maintenance hemodialysis. Clin Chem 31: 1314.

    PubMed  CAS  Google Scholar 

  12. Cronan CS, Schofield CL, 1979: Aluminum leaching response to acid precipitation: effects on high-elevation watersheds in the Northeast. Science 204: 304.

    Article  PubMed  CAS  Google Scholar 

  13. D’Haese PC, 1988: Aluminum accumulation in patients with chronic renal failure. Monitoring, diagnosis and therapy. PhD-thesis, University of Antwerp/Amsterdam.

    Google Scholar 

  14. Drüeke T, Lacour B, Touam M, Basile C, Bourdon R, 1985: Oral aluminum administration to uremic, hyperparathyroid, or vitamin D-supplemented rats. Nephron 39: 10.

    Article  PubMed  Google Scholar 

  15. Feinroth M, Feinroth MV, Berlyne GM, 1982: Aluminum absorption in the rat everted gut sac. Miner Electrolyte Metab 8: 29.

    PubMed  CAS  Google Scholar 

  16. Flendrig JA, Kruis H, Das HA, 1976: Aluminium and dialysis dementia. Lancet i: 1235.

    Google Scholar 

  17. Gacek EM, Babb AL, Uvelli DA, Fry DL, Scribner BH, 1979: Dialysis dementia: the role of dialysate pH in altering the dialyzability of aluminum. Trans Am Soc Artif Intern Organs 25: 409.

    PubMed  CAS  Google Scholar 

  18. Gorsky JE, Dietz AA, Spencer H, Osis D, 1979: Metabolic balance of aluminum studied in six men. Clin Chem 25: 1739.

    PubMed  CAS  Google Scholar 

  19. Greger JL, Baier MJ, 1983: Excretion and retention of low or moderate levels of aluminium by human subjects. Fd Chem Toxicol 21: 473.

    Article  CAS  Google Scholar 

  20. Hodge KC, Day JP, O’Hara M, Ackrill P, Ralston AJ, 1981: Critical concentrations of aluminium in water used for dialysis. Lancet ii: 802.

    Google Scholar 

  21. Hodsman AB, Sherrard DJ, Alfrey AC, Brickman AS, Miller A, Coburn JW, 1982: Bone aluminum and histomorphometric features of renal osteodystrophy. J Clin Endocrinol Metab 54: 539.

    Article  PubMed  CAS  Google Scholar 

  22. Hodsman AB, Anderson C, Leung F, 1984: Accelerated accumulation of aluminum by osteoid matrix in vitamin D deficiency. Miner Electrolyte Metab 10: 309.

    PubMed  CAS  Google Scholar 

  23. Ittel TH, Buddington B, Miller NL, Alfrey AC, 1987: Enhanced gastrointestinal absorption of aluminum in uremic rats. Kidney Int 32: 821.

    Article  PubMed  CAS  Google Scholar 

  24. Iyengar GV, Kollmer WE, Bowen HJM, 1978: The elemental composition of human tissues and body fluids. A compilation of values for adults. Verlag Chemie, Weinheim, FRG.

    Google Scholar 

  25. Kaehny WD, Hegg AP, Alfrey AC, 1977: Gastrointestinal absorption of aluminum from aluminum-containing antacids. N Engl J Med 296: 1389.

    Article  PubMed  CAS  Google Scholar 

  26. Klein GL, Ott SM, Alfrey AC, et al., 1982: Aluminum as a factor in the bone disease of long-term parenteral nutrition. Trans Assoc Am Phys 95: 155.

    PubMed  CAS  Google Scholar 

  27. Kovalchik MT, Kaehny WD, Hegg AP, Jackson JT, Alfrey AC, 1978: Aluminum kinetics during hemodialysis. J Lab Clin Med 92: 712.

    PubMed  CAS  Google Scholar 

  28. Malluche HH, Faugere, MC, Friedler RM, Matthews C, Fanti P, 1987: Calcitriol, parathyroid hormone, and accumulation of aluminum in bone of dogs with renal failure. J Clin Invest 79: 754.

    Article  PubMed  CAS  Google Scholar 

  29. Martin RB, 1986: The chemistry of aluminum as related to biology and medicine. Clin Chem 32: 1797.

    PubMed  CAS  Google Scholar 

  30. Martin RB, Savory J, Brown S, Bertholf RL, Wills MR, 1987: Transferrin binding of Al3+ and Fe3+. Clin Chem 33: 405.

    PubMed  CAS  Google Scholar 

  31. Mayor GH, Keiser JA, Makdani D, Ku PK, 1977: Aluminum absorption and distribution: effect of parathyroid hormone. Science 197: 1187.

    Article  PubMed  CAS  Google Scholar 

  32. Mayor GH, Sprague SM, Hourani MR, Sanchez TV, 1980: Parathyroid hormone-mediated aluminum deposition and egress in the rat. Kidney Int 17: 40.

    Article  PubMed  CAS  Google Scholar 

  33. McDermott JR, Smith AI, Iqbal K, Wisniewski HM, 1979: Brain aluminum in aging and Alzheimer disease. Neurology 29: 809.

    PubMed  CAS  Google Scholar 

  34. McLaughlin AIG, Kazantzis G, King E, Teare D, Porter RJ, Owen R, 1962: Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminium dust. Br J Ind Med 19: 253.

    PubMed  CAS  Google Scholar 

  35. Parkinson IS, 1981: Aluminium: evidence of toxicity in uraemic man. PhD Thesis, University of Newcastle upon Tyne.

    Google Scholar 

  36. Platts MM, Goode GC, Hislop JS, 1977: Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis. Br Med J 2: 657.

    Article  PubMed  CAS  Google Scholar 

  37. Platts MM, Anastasiades E, 1981: Dialysis encephalopathy: precipitating factors and improvement in prognosis. Clin Nephrol 15: 223.

    PubMed  CAS  Google Scholar 

  38. Sedman AB, Miller NL, Warady BA, Lum GM, Alfrey AC, 1984: Aluminum loading in children with chronic renal failure. Kidney Int 26: 201.

    Article  PubMed  CAS  Google Scholar 

  39. Simon P, Allain P, Mauras Y, Ang KS, 1982: Hyperaluminemia test (HAT) by desferoxamine (DFA) for the determination of tissue aluminum overload (TAO) in hemodialysis patients. Aggravating factor of chronic injections by B and non-A, non-B virus. Kidney Int 21: 900.

    Google Scholar 

  40. Sjogren B, Lundberg I, Lidums V, 1983: Aluminium in the blood and urine of industrially exposed workers. Br J Ind Med 40: 301.

    PubMed  CAS  Google Scholar 

  41. Skalsky HL, Carchman RA, 1983: Aluminum Homeostasis in man. J Am Coll Toxicol 2: 405.

    CAS  Google Scholar 

  42. Slanina P, Freeh W, Bernhardson A, Cedergren A, Mattsson P, 1985: Infuence of dietary factors on aluminum absorption and retention in the brain and bone of rats. Acta Pharmacol Tox 56: 331.

    Article  CAS  Google Scholar 

  43. Tomson CRV, Ward MK, 1989: Aluminium toxicity in renal failure. In: ‘Replacement of renal function by dialysis’. John F Maher (Ed.), 3rd edition: p. 1004.

    Google Scholar 

  44. Trapp GA, 1983: Plasma aluminum is bound to transferrin. Life Sci 33: 311.

    Article  PubMed  CAS  Google Scholar 

  45. Van de Vyver FL, Van Waeleghem JP, De Broe ME, D’Haese P, Heyndrickx A, 1982: Water treatment and dialysis dementia. Lancet ii: 1106.

    Google Scholar 

  46. Van de Vyver FL, De Broe ME, 1985: Aluminum in tissues. Clin Nephrol 24 (suppl 1): S37.

    PubMed  Google Scholar 

  47. Van de Vyver FL, Bekaert AB, D’Haese PC, Kellinghaus H, Graefe U, De Broe ME, 1986: Serum, blood, bone and liver aluminum levels in chronic renal failure. Trace Elem Med 3: 52.

    Google Scholar 

  48. Verbueken AH, Van de Vyver FL, Van Grieken RE, Paulus GJ, Visser WJ, D’Haese PC, De Broe ME 1984: Ultrastructural localization of aluminum in patients with dialysis- associated osteomalacia. Clin Chem 30: 763.

    PubMed  CAS  Google Scholar 

  49. Weast RC, Astle MJ, 1980: CRC handbook of chemistry. 61st edition, CRC Press Cleveland, Ohio.

    Google Scholar 

  50. Weiberg R, Berstad A, 1986: Gastrointestinal absorption of aluminium from single doses of aluminium containing antacids in man. Eur J Clin Invest 16: 428.

    Article  Google Scholar 

  51. Williams JW, Vera SR, Peters TG, et al., 1986: Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. Ann Intern Med 104: 782.

    PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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van de Vyver, F.L., D’Haese, P.C., de Broe, M.E. (1990). The metabolism of aluminum. In: de Broe, M.E., Coburn, J.W. (eds) Aluminum and renal failure. Developments in Nephrology, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1868-9_3

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  • DOI: https://doi.org/10.1007/978-94-009-1868-9_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7333-2

  • Online ISBN: 978-94-009-1868-9

  • eBook Packages: Springer Book Archive

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