Advertisement

Experimental aluminum induced bone disease

  • Mariano Rodriguez
  • Arnold J. Felsenfeld
  • Francisco Llach
Chapter
Part of the Developments in Nephrology book series (DINE, volume 26)

Abstract

The association of aluminum toxicity on the development of osteomalacia and aplastic bone disease in dialysis patients is a subject of major research interest. To study the adverse effect of aluminum on bone, experimental animal models of aluminum induced bone disease have been developed. Although an exact duplication of the bone disease observed in dialysis patients has not been achieved, morphological changes resembling those observed in patients have been produced in the various experimental models of aluminum intoxication. The importance of these animal models is not that they accurately reproduce the disease but that they are useful in studying the mechanisms of bone aluminum toxicity.

Keywords

Normal Renal Function Osteoblastic Activity Aluminum Toxicity Parathyroid Cell Mineralization Front 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Berlyne GM, Ari JB, Knopf E, Yagil R, Weinberger G and Danovitch GM, 1972: Aluminum toxicity in rats. Lancet 1: 564.PubMedCrossRefGoogle Scholar
  2. 2.
    Ellis HAJ, McCarthy JH, and Herrington J, 1979: Bone aluminum in haemodialysed patients and in rats injected with aluminum chloride: Relationship to impaired bone mineralization. J Clin Pathol 32: 832.PubMedCrossRefGoogle Scholar
  3. 3.
    Robertson JA, Felsenfeld AJ, Haygood CC, Wilson P, Clarke C, and Llach F, 1983: Animal model of aluminum-induced osteomalacia: Role of chronic renal failure. Kidney Int 23: 327.PubMedCrossRefGoogle Scholar
  4. 4.
    Chan YL, Alfrey AC, Posen S, Lissner D, Hills E, Dunstan CR, and Evans RA, 1983: Effect of aluminum on normal and uremic rats: Tissue distribution, vitamin D metabolites, and quantitative bone histology. Calcif Tissue Int 35: 344.PubMedCrossRefGoogle Scholar
  5. 5.
    Goodman WG, 1984: Short-term aluminum administration in the rat: Reduction in bone formation without osteomalacia. J Lab Clin Med 103: 749.PubMedGoogle Scholar
  6. 6.
    Goodman WG, Gilligan J, and Horst R, 1984: Short-term aluminum administration in the rat: Effects on bone formation and relationship to renal osteomalacia. J Clin Invest 73: 171.PubMedCrossRefGoogle Scholar
  7. 7.
    Goodman WG, 1985: The differential response of cortical and trabecular bone to aluminum administration in the rat. Proc Soc Exp Biol Med 179: 509.PubMedGoogle Scholar
  8. 8.
    Goodman WG, Henry DA, Horst R, Nudelman RK, Alfrey AC, and Goodman JW, 1984: Parenteral aluminum administration in the dog: II. Induction of osteomalacia and effect of vitamin D metabolism. Kidney Int 25: 370.PubMedCrossRefGoogle Scholar
  9. 9.
    Henry HL, and Norman A, 1985: Interactions between aluminum and the actions and metabolism of vitamin D3 in the chick. Calcif Tissue Int 37: 484.PubMedCrossRefGoogle Scholar
  10. 10.
    Finch JL, Bergfeld M, Martin KJ, Chan YL, Teitelbaum S, and Slatopolsky E, 1986: The effects of discontinuation of aluminum expose on aluminum-induced osteomalacia. Kidney Int 30: 318.PubMedCrossRefGoogle Scholar
  11. 11.
    Quarles LD, Dennis VW, Gitelman HJ, Harrelson JM, and Drezner MK, 1985: Aluminum deposition at the osteoid-bone interface. An epiphenomenon of the osteo-malacic state in vitamin D-deficient dogs. J Clin Invest 75: 1441.PubMedCrossRefGoogle Scholar
  12. 12.
    Sedman AB, Alfrey AC, Miller NL, and Goodman WG, 1987: Tissue and cellular basis for impaired bone formation in aluminum-related osteomalacia in the pig. J Clin Invest 79: 86.PubMedCrossRefGoogle Scholar
  13. 13.
    Talwar HS, Reddi AH, Menczel J, Thomas WC Jr., and Meyer JL, 1986: Influence of aluminum on mineralization during matrix-induced bone development. Kidney Int 29: 1038.PubMedCrossRefGoogle Scholar
  14. 14.
    Ikeda K, Matasumoto T, Morita K, Kurokawa K, and Ogata E, 1986: Inhibition of in vitro mineralization by aluminum in a clonal osteoblastlike cell line, MC3T3-E1. Calcif Tissue Int 39: 319.PubMedCrossRefGoogle Scholar
  15. 15.
    Liu CC, and Howard GA, 1984: Effects of aluminum on bone, in vitro. Clin Res 32: 50A.Google Scholar
  16. 16.
    Blumenthal NC, and Posner AS, 1984: In vitro model of aluminum-induced osteomalacia: Inhibition of hydroxy-apatite formation and growth. Calcif Tissue Int 36: 439.PubMedCrossRefGoogle Scholar
  17. 17.
    Christoffersen ME, and Christoffersen J, 1985: The effect of aluminum on the rate of dissolution of calcium hydroxyapatite-a contribution to the understanding of aluminum- induced bone diseases. Calcif Tissue Int 37: 673.PubMedCrossRefGoogle Scholar
  18. 18.
    Lieberherr M, Grosse B, Cournot-Witmer G, Hermann-Erlee MPM, and Balsan S, 1987: Aluminum action on mouse bone cell metabolism and response to PTH and 1, 25 (OH)2D3. Kidney Int 31: 736.PubMedCrossRefGoogle Scholar
  19. 19.
    Felsenfeld A, Rodriguez M, and Llach F, 1987: The evolution of osteomalacia in the rat with acute aluminum toxicity. (Abstract). Book of Abstracts, Xth International Congress of Nephrology, p. 158.Google Scholar
  20. 20.
    Alfrey AC, Sedman A, and Chan YL, 1985: The compartmentalization and metabolism of aluminum in uremic rats. J Lab Clin Med 105: 227.PubMedGoogle Scholar
  21. 21.
    Ittel TH, and Sieberth HG, 1987: Enhanced gastrointestinal absorption of aluminum in uremia: Kinetics and effect of vitamin D. ( Abstract ). Xth International Congress of Nephrology, p. 430.Google Scholar
  22. 22.
    Mayor GH, Keiser JA, and Ku PK, 1977: Aluminum absorption and distribution: Effect of parathyroid hormone. Science 197: 1187.PubMedCrossRefGoogle Scholar
  23. 23.
    Felsenfeld AJ, Harrelson JM, Gutman RA, Wells SA, and Drezner MK, 1982: Ann Intern Med 96: 34.PubMedGoogle Scholar
  24. 24.
    Andress DL, Ott SM, Maloney NA, Sherrard D, 1985: Effect of parathyroidectomy on bone aluminum accumulation in chronic renal failure. N Eng J Med 312: 468.CrossRefGoogle Scholar
  25. 25.
    Goodman WG, 1987: Thyroparathyroidectomy modifies the skeletal response to aluminum loading in the rat. Kidney Int 31: 923.PubMedCrossRefGoogle Scholar
  26. 26.
    Lewis-Finch J, Bergfeld M, Martin IK, Teitelbaum S, and Slatopolsky E, 1986: Hypoparathyroidism is essential for development of aluminum-induced osteomalacia in rats. (Abstract). Kidney Int 29: 218.Google Scholar
  27. 27.
    Quarles LD, Gitelman JJ, and Drezner MK, 1987: Aluminum effects on bone: Modulation by parathyroid hormone deficiency. ( Abstract ). Xth International Congress of Nephrology, p. 440, 1987.Google Scholar
  28. 28.
    Malluche HH, Faugere MC, Friedler RM, Matthews C, Fanti P, 1987: Calcitriol, parathyroid hormone, and accumulation of aluminum in bone in dogs with renal failure. J Clin Invest 79: 754.PubMedCrossRefGoogle Scholar
  29. 29.
    Hodsman AB, Anderson C, Leung FY, 1984: Accelerated accumulation of aluminum by osteoid matrix in vitamin D deficiency. An animal model of aluminum toxicity. Min Electrolyte Metab 10: 309.Google Scholar
  30. 30.
    Burnatowska-Hledin MA, Doyle TM, Eadie MJ, and Mayor GH, 1986: 1, 25 dihydroxyvita- min D3 increases serum and tissue accumulation of aluminum in rats. J Lab Clin med 108: 96.Google Scholar
  31. 31.
    Adler AJ, and Berlyne GM, 1985: Duodenal aluminum absorption in the rat: Effect of vitamin D. Am J Physiol 249: G209.PubMedGoogle Scholar
  32. 32.
    Drueke T, Lacour B, Touam M, Basile C, Bourdon R, 1985: Oral aluminum administration to uremic, hyperparathyroid, or vitamin D supplemented rats. Nephron 39: 10.PubMedCrossRefGoogle Scholar
  33. 33.
    Andress D, Felsenfeld AJ, Voigts A, and Llach F, 1983: Parathyroid hormone response to hypocalcemia in hemo-dialysis patients with osteomalacia. Kidney Int 24: 364.PubMedCrossRefGoogle Scholar
  34. 34.
    Cann C, Prussin SG, and Gordon GS, 1979: Aluminum uptake by the parathyroid glands. J Clin Endocrinol and Metab 49: 543.CrossRefGoogle Scholar
  35. 35.
    Morissey J, Slatopolsky E, 1986: The effect of aluminum on parathyroid hormone secretion. Kidney Int 29 (S 18): S41.Google Scholar
  36. 36.
    Slatopolsky E, 1987: The interaction of parathyroid hormone and aluminum in renal osteodystrophy. Kidney Int 31: 842.PubMedCrossRefGoogle Scholar
  37. 37.
    Bellorin-Font E, Weaver ME, Stokes TJ, McConkey C Jr., Slatopolsky E, and Martin KJ, 1985: Effects of aluminum on bovine parathyroid adenylate cyclase. Endocrinology 117: 1456.PubMedCrossRefGoogle Scholar
  38. 38.
    Bourdeau AM, Plachot JJ, Cournot-Witmer G, Pointillart A, Balsan S, and Sachs C, 1987: Parathyroid response to aluminum in vitro: Ultrastructural changes and PTH release. Kidney Int 31: 15.Google Scholar
  39. 39.
    Diaz JB, Verbueken AH, Nouwen EJ, D’Haese PC, Lamberts LV, and DeBroe ME, 1987: Aluminum uptake by the parathyroid glands and its subcellular localization in parathyroid cells. (Abstract). Xth International Congress of Nephrology. Book of Abstracts, p. 421.Google Scholar
  40. 40.
    Cannata JB, Allende MT, De Francisto AL, Diaz de Grenu MC, Fernandez MD, Sanz- Medel A, 1987: Parathyroid hormone response in clinical and experimental hyper- aluminaemia. ( Abstract ). Xth International Congress of Nephrology, p. 418.Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Mariano Rodriguez
  • Arnold J. Felsenfeld
  • Francisco Llach

There are no affiliations available

Personalised recommendations