Abstract
Immunoglobulin synthesis is mediated by several cytokines including IL-4, IL-5 and IL-6 which induce activation, proliferation and differentiation of B cells. Among these ILs, IL-6 has been cloned and described as a potent cytokine for the terminal differentiation of B cells to high Ig secreting plasma cells [1]. Further, a receptor for IL-6 has been cloned and was found only on activated and dividing but not resting B cells [2,3]. To this end, pokeweed mitogen (PWM) stimulated peripheral blood mononuclear cells (PBMC) were sensitive to recombinant human IL-6 (rhIL-6), where significant augmentation of Ig synthesis was noted in all isotypes [1, 4]. Furthermore, incubation of blast cells isolated from mitogen preactivated B cells with rhIL-6 resulted in enhancement of Ig synthesis.
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© 1990 Kluwer Academic Publishers
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Fujihashi, K. et al. (1990). Regulation of human IgA and IgA subclass synthesis by recombinant interleukin-6. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_36
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DOI: https://doi.org/10.1007/978-94-009-1848-1_36
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