Abstract
The factors regulating the differentiation of IgA B cells has been an area of great interest to mucosal immunologists as well as those interested in B cell differentiation generally. It is now clear that such differentiation involves two major steps, first, isotype switch differentiation of sIgM B cells (surface IgM-bearing B cells) into sIgA B cells (surface IgA-bearing B cells) and second, terminal differentiation of IgA B cells into IgA producing plasma cells. It has also become evident that both of these steps are regulated processes that are under the influence of various cytokines and lymphokines. In the present study we address this latter point by presenting data that further defines the role of cytokines and lymphokines in the regulation of IgA B cell differentiation. In particular, we show that IL-4 may play a role in the switch differentiation step of IgA B cells and that IL-5 and IL-6 are important in the terminal differentiation step of these B cells.
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References
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© 1990 Kluwer Academic Publishers
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Harriman, G.R., Strober, W. (1990). Cytokine/lymphokine regulation of IgA B cell differentiation. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_30
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DOI: https://doi.org/10.1007/978-94-009-1848-1_30
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7323-3
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