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HML-1, an antibody raised against intestinal lymphocytes, recognises an antigen appearing on activated peripheral blood lymphocytes

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Advances in Mucosal Immunology

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Abstract

The monoclonal antibody HML-1 [1] recognizes about 95% of intraepithelial lymphocytes and to a lower extent lamina propria lymphocytes (LPL) and mesenteric lymphoblasts. In order to characterize T cells expressing HML-1 in the lamina propria we investigated the number of HML-1 positive cells and their distribution on the T cell subsets CD4 and CD8. Since LPL are known to have an increased state of activation when compared to lymphocytes of other origin [2] we also investigated the in vitro inducibility of HML-1 on PBL.

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References

  1. Cerf-Bensussan, N., Jarry, A., Brousse, N., Liskowska-Grospierre, B., Guy- Grand, D., and Griscelli, C. (1987) ‘A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes’, Eur. J. Immunol., 17, 1279–85

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  2. Zeitz, M., Greene, W.C., Pfeffer, N.J., and James, S.P. (1988) ‘Lymphocytes isolated from the intestinal Lamina propria of normal nonhuman primates have increased expression of genes associated with T cell activation’, Gastroenterology, 94, 647–55

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  3. Stoolman, L.M. (1989) ‘Adhesion Molecules Controlling Lymphocyte Migration’, Cell, 56, 907–10

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Author information

Authors and Affiliations

  1. Department of Medicine and Pathology, Klinikum Steglitz, Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, West Germany

    H L Schieferdecker, R Ullrich, A N Weiss-Breckwoldt, R Schwarting, H Stein, E O Riecken & M Zeitz

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  1. H L Schieferdecker
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  2. R Ullrich
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  3. A N Weiss-Breckwoldt
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  4. R Schwarting
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  5. H Stein
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  6. E O Riecken
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  7. M Zeitz
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Editor information

Editors and Affiliations

  1. Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK

    Thomas T MacDonald PhD MRCPath (Wellcome Senior Lecturer) (Wellcome Senior Lecturer)

  2. Department of Oral Medicine and Pathology, Guy’s Hospital, London, UK

    Stephen J Challacombe PhD BDS MRCPath (Professor) (Professor)

  3. Department of Veterinary Medicine, The University, Bristol, UK

    Paul W Bland PhD (Lecturer) & Christopher R Stokes PhD (Senior Research Fellow) (Lecturer) &  (Senior Research Fellow)

  4. Department of Medicine, St James’s University Hospital, London, UK

    Richard V Heatley MD MRCP (Senior Lecturer) (Senior Lecturer)

  5. Department of Bacteriology and Immunology, The University, Glasgow, UK

    Allan Mcl Mowat PhD MB ChB (Lecturer) (Lecturer)

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© 1990 Kluwer Academic Publishers

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Schieferdecker, H.L. et al. (1990). HML-1, an antibody raised against intestinal lymphocytes, recognises an antigen appearing on activated peripheral blood lymphocytes. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_23

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  • DOI: https://doi.org/10.1007/978-94-009-1848-1_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7323-3

  • Online ISBN: 978-94-009-1848-1

  • eBook Packages: Springer Book Archive

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