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Helicobacter pylori infection in children

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Helicobacter pylori

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Abstract

Helicobacter pylori infection occurs mainly in children. Studies on children are therefore vital if we are to answer many of the questions relating to this important global infection. The mode of transmission of H. pylori, and the risk of reinfection following treatment, can be evaluated adequately only in children. Epidemiological studies involving children depend on the validation of non-invasive methods for the diagnosis of H. pylori. Because relatively few children in developed countries are infected, they are an excellent population in which to evaluate whether or not specific symptoms are associated with H. pylori gastritis. The recent classification of H. pylori as a Group 1 carcinogen must stimulate us to evaluate the need to treat all children with this infection.

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References

  1. Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1:1273–5.

    Google Scholar 

  2. Goodwin CS, Armstrong JA, Marshall BJ. Campylobacter pyloridis, gastritis and peptic ulceration. J Clin Pathol. 1986;39:353–65.

    Article  PubMed  CAS  Google Scholar 

  3. Blaser MJ. Gastric Campylobacter-like organisms, gastritis and peptic ulcer disease. Gastro-enterology. 1987;93:371–83.

    CAS  Google Scholar 

  4. Drumm B, Sherman P, Cutz E, Karmali M. Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med. 1987;316:1557–61.

    Article  PubMed  CAS  Google Scholar 

  5. Drumm B, Perez-Perez GI, Blaser MJ, Sherman PM. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med. 1990;322:359–63.

    Article  PubMed  CAS  Google Scholar 

  6. Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV. Campylobacter pyloridis and acid-induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol. 1987;40:841–8.

    Article  PubMed  CAS  Google Scholar 

  7. Pauli G, Yardley J. Gastric and oesophageal Campylobacter pylori in patients with Barett’s oesophagus. Gastroenterology. 1988;95:216–18.

    Google Scholar 

  8. Morris A, Nicholson G, Zwi J, Vanderwee M. Campylobacter pylori infection in Meckel’s diverticula containing gastric mucosa. Gut. 1989;30:1233–5.

    Article  PubMed  CAS  Google Scholar 

  9. Pambianco D, Dye K, Marshall B et al. Gastritis in the rectum: Campylobacter-like organisms in heterotrophic inflamed gastric mucosa. Gastroenterology. 1988;94:A340.

    Google Scholar 

  10. Yeung CK, Fu KH, Yuen KY et al. Helicobacter pylori and associated duodenal ulcer. Arch Dis Child. 1990;65:1212–16.

    Article  PubMed  CAS  Google Scholar 

  11. Israel D, Hassall E. Treatment and long term follow-up of Helicobacter pylori and associated duodenal ulcer. Arch Dis Child. 1990;123:53–8.

    Google Scholar 

  12. Hassall E, Dimmick JE. Unique features of Helicobacter pylori disease in children. Dig Dis Sci. 1991;36:417–23.

    Article  PubMed  CAS  Google Scholar 

  13. Bertram TA, Krakowka S, Morgan DR. Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine. Rev Infect Dis. 1991;13(Suppl. 8):S414–423.

    Article  Google Scholar 

  14. Dooley CP, Cohen H. The clinical significance of Campylobacter pylori. Ann Intern Med. 1988; 108:70–9.

    PubMed  CAS  Google Scholar 

  15. Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med. 1991;324:1043–8.

    Article  PubMed  CAS  Google Scholar 

  16. Marshall BJ, Goodwin CS, Warren JR et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988;2:1437–42.

    Article  PubMed  CAS  Google Scholar 

  17. Coughlan JG, Gilligan D, Humphries H et al. Campylobacter pylori and recurrence of duodenal ulcers — a 12 month follow up study. Lancet. 1987;2:1109–11.

    Article  Google Scholar 

  18. Hentschel E, Brandstatter G, Dragosics B et al. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcers. N Engl J Med. 1993;328:308–12.

    Article  PubMed  CAS  Google Scholar 

  19. Drumm B, Sherman P, Chiasson D, Karmali M, Cutz E. Treatment of Campylobacter pylori-associated antral gastritis in children with bismuth subsalicylate and ampicillin. J Pediatr. 1988; 113:908–12.

    Article  PubMed  CAS  Google Scholar 

  20. Goggin N, Rowland M, Clyne M, Drumm B. Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease. Proc Br Paediatr Assoc. 1995;78:42.

    Google Scholar 

  21. Goodwin CS. Duodenal ulcer, Campylobacter pylori and the ‘leaking roof’ concept. Lancet. 1988;2:1467–9.

    Article  PubMed  CAS  Google Scholar 

  22. Shabib S, Cutz E, Drumm B, Sherman P. Helicobacter pylori infection is associated with gastric metaplasia in the duodenum. Am J Clin Pathol. 1994;102:188–91.

    PubMed  CAS  Google Scholar 

  23. Gormally SM, Kierse B, Daly L, Bourke W, Dumin M, Drumm B. Gastric metaplasia and duodenal ulcer disease in children. Gut. 1996;38:513–17.

    Article  PubMed  CAS  Google Scholar 

  24. Megraud F, Brassens-Rabbe MP, Denis F, Belbouri A, Hoa DQ. Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol. 1989;27:1870–3.

    PubMed  CAS  Google Scholar 

  25. Banatvala N, Mayo K, Megraud F, Jennings R, Deeks JJ, Feldman RA. The cohort effect and Helicobacter pylori. J Infect Dis. 1993;168:219–21.

    Article  PubMed  CAS  Google Scholar 

  26. Cullen DJE, Collins BJ, Christiansen KJ et al. When is Helicobacter pylori infection acquired? Gut. 1993;34:1681–2.

    Article  PubMed  CAS  Google Scholar 

  27. Parsonnet J, Blaser MJ, Perez-Perez GI, Hargrett-Bean N, Tauxe RV. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology. 1992;102:41–6.

    PubMed  CAS  Google Scholar 

  28. Dooley CP, Cohen H, Fitzgibbons PL et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 1989;321:1562–6.

    Article  PubMed  CAS  Google Scholar 

  29. Crabtree JE, Shallcross TM, Wyatt JI et al. Mucosal immune responses to Helicobacter pylori in patients with duodenitis. Dig Dis Sci. 1991;36:1266–73.

    Article  PubMed  CAS  Google Scholar 

  30. Borody T, Andrews P, Mancuso N, Jankiewicz E, Brandl S. Helicobacter pylori reinfection 4 years post eradication. Lancet. 1992;339–1295.

    Google Scholar 

  31. Forbes GM, Glaser ME, Cullen DJE et al. Duodenal ulcer treated with Helicobacter pylori eradication: seven year follow-up. Lancet. 1994;343:258–60.

    Article  PubMed  CAS  Google Scholar 

  32. Graham DY, Adam E, Reddy GT et al. Seroepidemiology of Helicobacter pylori infection in India. Dig Dis Sci. 1991;36:1084–8.

    Article  PubMed  CAS  Google Scholar 

  33. Fiedorek SC, Malaty HM, Evans DI et al. Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics. 1991;88:578–82.

    PubMed  CAS  Google Scholar 

  34. Sitas F, Forman D, Yarnell JWG et al. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut. 1991;32:25–8.

    Article  PubMed  CAS  Google Scholar 

  35. Webb PM, Knight T, Greaves S et al. Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. Br Med J. 1994;308:750–3.

    CAS  Google Scholar 

  36. Teh BH, Lin JT, Pan WH et al. Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. Anticancer Res. 1994;14:1389–92.

    PubMed  CAS  Google Scholar 

  37. Shames B, Krajden S, Fuksa M, Babida C, Penner JL. Evidence of occurrence of the same strain of Campylobacter pylori in the stomach and dental plaque. J Clin Microbiol. 1989;27:2849–50.

    PubMed  CAS  Google Scholar 

  38. Thomas JE, Gibson GR, Darboe MK, Dale A, Weaver LT. Isolation of Helicobacter pylori from human faeces. Lancet. 1992;340:1194–5.

    Article  PubMed  CAS  Google Scholar 

  39. Kelly SM, Pitcher MCL, Farmery SM, Gibson GR. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology. 1994;107:1671–4.

    PubMed  CAS  Google Scholar 

  40. Berkowicz J, Lee A. Person to person transmission of Campylobacter pylori. Lancet. 1987;2: 680–2.

    Article  PubMed  CAS  Google Scholar 

  41. Nwokolo CU, Bickley J, Attard AR, Owen RJ, Costas M, Fraser IA. Evidence of clonal variants of Helicobacter pylori in three generations of a peptic ulcer disease family. Gut. 1992;33:1323–7.

    Article  PubMed  CAS  Google Scholar 

  42. Bamford KB, Bickley J, Collins JSA et al. Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection. Gut. 1993;34:1348–50.

    Article  PubMed  CAS  Google Scholar 

  43. Simor AE, Shames B, Drumm B, Sherman P, Low DE, Penner JL. Typing of Campylobacter pylori by bacterial DNA restriction endonuclease analysis and determination of plasmid profile. J Clin Microbiol. 1990;28:83–6.

    PubMed  CAS  Google Scholar 

  44. Handt LK, Fox JG, Dewhirst FE et al. Helicobacter pylori isolated from the domestic cat: public health implications. Infect Immun. 1994;62:2367–74.

    PubMed  CAS  Google Scholar 

  45. Fox JG, Batchwelder M, Marini R et al. Helicobacter pylori-induced gastritis in the domestic cat. Infect Immun. 1995;63:2674–81.

    PubMed  CAS  Google Scholar 

  46. IARC monographs on the evaluation of carcinogenic risks to humans. Schistosomes, liver flukes and Helicobacter pylori. Lyon: IARC; 1994;61:177–240.

    Google Scholar 

  47. Forman D, Newell DG, Fullerton F et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br Med J. 1991;302: 1302–5.

    Article  CAS  Google Scholar 

  48. Parsonnet J, Friedman GD, Vandersteen DP et al. Helicobacter pylori infection and risk for gastric cancer. N Engl J Med. 1991;324:1127–31.

    Article  Google Scholar 

  49. Nomura A, Stemmermann GN, Chyou PH, Kato J, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991;325:1133–6.

    Article  Google Scholar 

  50. Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 1995;55:562–5.

    PubMed  CAS  Google Scholar 

  51. Blaser MJ, Parsonnet I. Parasitism by the ‘slow’ bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest. 1994;94:4–8.

    Article  PubMed  CAS  Google Scholar 

  52. Howson CP, Hiyama T, Wynder EL. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27.

    PubMed  CAS  Google Scholar 

  53. Sipponen P. Helicobacter pylori infection — a common worldwide environmental risk factor for gastric cancer? Endoscopy. 1992;24:424–7.

    Article  PubMed  CAS  Google Scholar 

  54. Correa P. Is gastric carcinoma an infectious disease? N Engl J Med. 1991;325:1170–1.

    Article  PubMed  CAS  Google Scholar 

  55. Blecker U, Hauser B, Lanciers S, Peeters S, Suys B, Vandenplas Y. The prevalence of Helicobacter pylori-positive serology in asymptomatic children. J Pediatr Gastroenterol Nutr. 1993; 16:252–6.

    Article  PubMed  CAS  Google Scholar 

  56. Fiedorek SC, Casteel HB, Pumphrey CL et al. The role of Helicobacter pylori in recurrent functional abdominal pain in children. Am J Gastroenterol. 1992;87:347–9.

    PubMed  CAS  Google Scholar 

  57. van der Meer SB, Forget PP, Loffeld RJLF, Stobberingh E, Kuijten RH, Arends JW. The prevalence of Helicobacter pylori serum antibodies in children with recurrent abdominal pain. Eur J Pediatr. 1992;151:799–801.

    Article  PubMed  Google Scholar 

  58. Reifen R, Rasooly I, Drumm B, Millson ME, Murphy K, Sherman PM. Symptomatology and demographic features of Helicobacter pylori infection in children. Dig Dis Sci. 1994;39:1488–92.

    Article  PubMed  CAS  Google Scholar 

  59. Gormally SM, Prakash N, Durnin M et al. Symptoms in children before and after treatment of Helicobacter pylori. Gastroenterology. 1994; 106: A83.

    Google Scholar 

  60. De Giacomo C, Fiocca R, Villani L et al. Helicobacter pylori infection and chronic gastritis: clinical, serological and histologic correlations in children treated with amoxicillin and colloidal bismuth subcitrate. J Pediatr Gastroenterol Nutr. 1990; 11:310–16.

    Article  PubMed  Google Scholar 

  61. Mahony MJ, Wyatt JI, Littlewood JM. Management and response to treatment of Helicobacter pylori gastritis. Arch Dis Child. 1992;67:940–3.

    Article  PubMed  CAS  Google Scholar 

  62. Elta GH, Appleman HD, Behler EM, Wilson JA, Nostrani TJ. A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis. Am J Gastroenterol. 1987;82:749–53.

    PubMed  CAS  Google Scholar 

  63. Drumm B. Helicobacter pylori and the pediatric patient. Gastroenterol Clin N Am. 1993;22: 169–82.

    CAS  Google Scholar 

  64. McNulty CAM, Dent JC, Uff JS, Gear MW, Wilkinson SP. Detection of Campylobacter pylori by the biopsy urease test: an assessment in 1445 patients. Gut. 1989;30:1058–62.

    Article  PubMed  CAS  Google Scholar 

  65. Carvalho AST, Queiroz DMM, Mendes EN, Rocha GA, Penna FJ. Diagnosis and distribution of Helicobacter pylori in the gastric mucosa of symptomatic children. Braz J Med Biol Res. 1991; 24:163–6.

    PubMed  CAS  Google Scholar 

  66. Czinn SJ, Carr HS, Speck WT. Diagnosis of gastritis caused by Helicobacter pylori in children by means of an ELISA. Rev Infect Dis. 1991;13:700–3.

    Article  Google Scholar 

  67. Crabtree JE, Mahony MJ, Taylor JD, Heatley RV, Littlewood JM, Tompkins DS. Immune responses to Helicobacter pylori in children with recurrent abdominal pain. J Clin Pathol. 1991;44:768–71.

    Article  PubMed  CAS  Google Scholar 

  68. Graham DY, Evans Jr DJ, Alpert LC et al. Campylobacter pylori detected noninvasively by the 13C-urea breath test. Lancet. 1987;1:1174–7.

    Article  PubMed  CAS  Google Scholar 

  69. Eggers RH, Kulp A, Tegeler R et al. A methodological analysis of the 13C-urea breath test for detection of Helicobacter pylori infections: high sensitivity and specificity within 30 min using 75 mg of 13C-urea. Eur J Gastroenterol Hepatol. 1990;2:437–44.

    Google Scholar 

  70. Slomianski A, Schubert T, Cutler AF. 13C-urea breath test to confirm eradication of Helicobacter pylori. Am J Gastroenterol. 1995;90:224–6.

    PubMed  CAS  Google Scholar 

  71. Rowland M, Lambert I, Gormally S et al. 13C-urea breath test for the diagnosis of Helicobacter pylori infection in children. Proc BPA. 1996;68:46.

    Google Scholar 

  72. Oderda G, Dell’olio D, Morra I, Ansaldi N. Campylobacter pylori gastritis: long term results of treatment with amoxycillin. Arch Dis Child. 1989;64:326–9.

    Article  PubMed  CAS  Google Scholar 

  73. Queiroz DMM, Moura SB, Mendes EN, Rocha GA, Barbosa AJA, de Carvalho AST. Effect of Helicobacter pylori eradication on G-cell and D-cell density in children. Lancet. 1994;343: 1191–3.

    Article  PubMed  CAS  Google Scholar 

  74. Yousfi MM, El-Zimaity HMT, Al-Assi MT, Cole RA, Genta RM, Graham DY. Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection. Aliment Pharmacol Ther. 1995;9:209–12.

    Article  PubMed  CAS  Google Scholar 

  75. Ozmen MM, Johnson CD. Is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for Helicobacter pylori eradication? Am J Gastroenterol. 1995;90:1542–3.

    PubMed  CAS  Google Scholar 

  76. National Institutes of Health. Helicobacter pylori in peptic ulcer disease. NIH Consensus Statement. 1994;12:1–23.

    Google Scholar 

  77. Drumm B. Helicobacter pylori. Arch Dis Child. 1990;6:1278–82.

    Article  Google Scholar 

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Authors
  1. M. Rowland
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  2. B. Drumm
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Rowland, M., Drumm, B. (1996). Helicobacter pylori infection in children. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_29

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

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