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Essential co-factors in gastric carcinogenesis

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Helicobacter pylori

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Abstract

There is now a large body of evidence which supports the association between Helicobacter pylori infection and an increased risk of gastric cancer. This is reflected in the decision by the International Agency for Cancer Research to categorize H. pylori infection as a definite cause of human cancer1. It is, however, readily apparent that, whereas infection with H. pylori is an extremely common event, gastric cancer is a relatively rare outcome of such infection. For every 100 people infected, no more than five, and probably only one or two, are likely to develop a malignancy. This poses the problem of how to identify the small percentage of infected individuals who are at increased risk of cancer. Clearly unravelling the co-factors involved in the process may be of public health significance, and should help in improving the focus of screening programmes which have, as their objective, preventing the future occurrence of gastric cancer.

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Authors
  1. D. Forman
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Forman, D. (1996). Essential co-factors in gastric carcinogenesis. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_26

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_26

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

  • eBook Packages: Springer Book Archive

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