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Effects of infection with Helicobacter pylori on gastric epithelium

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Helicobacter pylori

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Abstract

There is growing evidence to support a key role for the gastric epithelium in the pathogenesis of Helicobacter pylori-associated gastroduodenal disorders. H. pylori is largely regarded as a non-invasive pathogen, yet is capable of inducing a significant inflammatory response. The concept that the epithelium could play an active role in H. pylori-associated inflammation has been substantiated over the past few years by work from several laboratories (reviewed by others in refs 1 and 2). In these studies gastric epithelial production of interleukin-8 (IL-8), a cytokine with potent neutrophil chemotactic and activating properties3,4, was significantly increased during H. pylori infection5–9. More recent data suggest that other chemokines including members of the C-C family that stimulate lymphocytes and monocytes/macrophages, are also expressed by gastric epithelial cells in response to H. pylori infection. Gastric epithelial cells are also capable of interacting with immune and inflammatory cells through adhesion or immune accessory molecules including Class II MHC, invariant chain (Ii), intracellular adhesion molecule (ICAM)-1, lymphocyte function antigen (LFA)-3, and B7. Expression of such molecules is increased by H. pylori infection with both direct and indirect events involved in the enhanced expression. Together, this information provides a basis to establish potential mechanisms whereby the epithelium can signal immune cells to establish the gastritis associated with H. pylori infection. In turn, immune or inflammatory cells may mediate alterations of the gastric epithelium that occur during H. pylori infection.

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Authors
  1. S. E. Crowe
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  2. X. Fan
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  3. S. Behar
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  4. G. Ye
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Crowe, S.E., Fan, X., Behar, S., Ye, G. (1996). Effects of infection with Helicobacter pylori on gastric epithelium. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_14

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_14

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