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Perioperative Myocardial Ischemia and Stroke—New Developments

  • Dennis T. Mangano
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 31)

Abstract

Cardiovascular disease continues to be the most significant healthcare risk. In the United States, more than 25% of the population has cardiovascular disease, with one out of every two deaths attributable to cardiovascular disease, and with more than one-third of the healthcare resources appropriated to the diagnosis and treatment of cardiovascular disease. The impact of cardiovascular disease on the surgical patients is substantial, as well. Regarding cardiac surgery, more than 350,000 coronary artery bypass graft procedures are performed annually in the United States, consuming over $10 billion a year in resources, and more than $1 billion for in-house and long-term costs of treating cardiovascular complications following surgery. Regarding noncardiac surgery, of the 25 million patients undergoing such surgery, approximately one-third have coronary artery disease, risk factors, or are over the age of 65 years. Four percent of this entire population, or approximately one million patients, suffer cardiovascular morbidity during the perioperative period, resulting in an overall in-hospital and long-term cost exceeding $22 billion annually in the United States.

Keywords

Coronary Artery Bypass Graft Surgery Stroke Rate Noncardiac Surgery Stroke Therapy Adverse Cardiovascular Outcome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mangano DT. Perioperative cardiac morbidity. Anesthesiology 72: 153–184, 1990PubMedCrossRefGoogle Scholar
  2. 2.
    National Center for Health Statistics: Health, United States 1099 DHHS Publication No. (PHS) 89–1232. Public Health Service, Washington, US Government Printing Office, March 1989, pp. 10–17, 66–67, 100–101Google Scholar
  3. 3.
    Frye RL, Higgins, MW, Beller GA, et al. Curry Task Force III: Major demographic and epidemiologic trends affecting adult cardiology. J Am Coll Cardio 12:840–846, 1988CrossRefGoogle Scholar
  4. 4.
    Mangano DT, Browner W, Hollenberg M, et al. Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. N Engl J Med 323:1781–1788, 1990PubMedCrossRefGoogle Scholar
  5. 5.
    Mangano DT. Multicenter outcome research. J Cardiovasc Anesth 8(Suppl l):l–3, 1994Google Scholar
  6. 6.
    McSPI Research Group Organizational Plan, 1992Google Scholar
  7. 7.
    Mangano DT, Hollenberg M, Fegert G, et al. Perioperative myocardial ischemia in patients undergoing noncardiac surgery. I. Incidence and severity during the four-day perioperative period. J Am Coll Cardiol 17:843–850, 1991PubMedCrossRefGoogle Scholar
  8. 8.
    Mangano DT, Wong MG, London MJ, et al. Perioperative myocardial ischemia in patients undergoing noncardiac surgery. II. Incidence and severity during the first week following surgery. J Am Coll Cardiol 17:851–857, 1991PubMedCrossRefGoogle Scholar
  9. 9.
    The McSPI Research Group: Effects of acadesine on morbidity and mortality following coronary artery bypass graft surgery. Circulation (in review, 1994)Google Scholar
  10. 10.
    Leung JM, Stanley T 3rd, Mathew J, Curling P, Barash P, Salmenpera M, Reves G, Hollenberg M, Mangano DT, SPI Research Group: An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. Anesth Analg 78:420–434, 1994PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Dennis T. Mangano

There are no affiliations available

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