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Cytokines and bacterial infections

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Cytokine Yearbook Volume 1

Abstract

During the recent 10–15 years a growing amount of knowledge has been accumulated on the role of cytokines in the pathogenesis and resistance to infections caused by nonviral agents, including a wide range of bacteria. Cytokines can be major mediators of the pathogenic effect in some diseases, and represent important defense mechanisms in others. Detailed knowledge on the role of the growing number of recognised cytokines is important, because it may represent means to combat and to prevent diseases caused by such infections.

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References

  1. Barnewall RE, Rikihisa Y. Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron transferrin. Infect Immun 1994; 62: 4804–10.

    PubMed  CAS  Google Scholar 

  2. Beatty WL, Belanger TA, Demi AA, Morrison RP, Byrne GI. Tryptophane depletion as a mechanism of gamma interferon-mediated chlamydial persistence. Infect Immun 1994; 62: 3705–11.

    PubMed  CAS  Google Scholar 

  3. Benabdehnoumene S, Dumont S, Petit C, Poindron D, Wachsmann D, Klein JP. Activation of human monocytes by Streptocossus mutans serotype f polysaccharide: immnoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production. Infect Immun 1991; 59: 3261–6.

    Google Scholar 

  4. Bermudez LE. Potential role of cytokines in disseminated mycobacterial infections. EurJ Clin Microbiol Infect Dis 1994; Suppl 2: 29–33.

    Article  Google Scholar 

  5. Beutler BA, Milsark IW, Cerami A. Cachectin/tumor necrosis factor: production, distribution and metabolic fate in vivo. J Immunol 1985; 135: 3872–977.

    Google Scholar 

  6. Black CM, Catterall JR, Remington JS. In vivo and in vitro activation of alveolar macrophages by recombinant interferon-y. J Immunol 1987; 138: 491–5.

    PubMed  CAS  Google Scholar 

  7. Blanchard ICD, Djeu JY, Klein TW, Friedman H, Stewart WE II. Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections in mice via activation of PMN function. J Leukocyte Biol 1988; 43: 429–35.

    PubMed  CAS  Google Scholar 

  8. Bukholm G, Degré M. Effect of human leukocyte interferon on invasiveness of Salmonella typhimurium in HEp-2 cells cultures. Infect Immun 1983; 42: 1198–202.

    PubMed  CAS  Google Scholar 

  9. Bukholm G, Berdal BP, Haug C, Degré M. Mouse fibroblast interferon modifies Salmonella typhimurium infection in infant mice. Infect Immun 1984; 45: 62–6.

    PubMed  CAS  Google Scholar 

  10. Bukholm G, Degré M. Effect of human gamma interferon on invasiveness of Salmonella typhimurium in HEp-2 cell cultures. J Interferon Res 1985; 5: 45–53.

    Article  PubMed  CAS  Google Scholar 

  11. Byrne GI, Beatty WL, Schoben CS. Cytokine-mediated antimicrobial events:mechanisms of action. In: Sonnenfeld G, Czamiecki C, Nacy C, Byrne GI, Degré M, eds. Cytokines and resistance to nonviral pathogenic infections. Augusta: Biomedical Press, 1992: 169–76.

    Google Scholar 

  12. Champsi JH, Bermudez LE, Young LS. The role of cytokines in mycobacterial infection. Biotherapy 1994; 7: 187–93.

    Article  PubMed  CAS  Google Scholar 

  13. De Boer JP, Wolbing GJ, Thijs LG, Baars JW, Wagstaff J, Hack CE. Interplay of complement and cytokines in the pathogenesis of septic shock. Immunopharm 1992; 24: 135–44.

    Article  Google Scholar 

  14. Degré M, Dahl H. Production of an interferon-like agent following inoculation with bacterial vaccine. Proc Soc Exp Biol Med 1971; 137: 233–6.

    PubMed  Google Scholar 

  15. Degré M, Bukholm G, Czamiecki CW. In vitro treatment of HEp-2 cells with human tumor necrosis factor and human interferon reduces invasiveness of Salmonella typhimurium. J Biol Regul Homeost Agents 1989; 3: 1–7.

    PubMed  Google Scholar 

  16. Degré M, Bukholm G. Effect of tumor necrosis factor-a on infection with Salmonella typhimurium in a mouse model. J Biol Regul Homeost Agents 1990; 4: 157–61.

    PubMed  Google Scholar 

  17. Denis M. Human monocytes/macrophages: NO or NO? J Leukoc Biol 1994; 55: 682–4.

    PubMed  CAS  Google Scholar 

  18. Djeu JY, Serbousek D, Blanchard DK. Release of tumor necrosis factor by polymorphonuclear leukocytes. Blood 1990; 76: 1405–90.

    PubMed  CAS  Google Scholar 

  19. Flick DA, Gifford GE. Pharmacokinetics of murine tumor necrosis factor. J Immunopharmacol 1986; 8: 89–97.

    Article  PubMed  CAS  Google Scholar 

  20. Fong Y, Tracey KJ, Moldawer LL, Hesse DG, Manogue KB, Kenney JS, Lee AT, Kuo GC, Allison AC, Lowry SF, Cerami C. Antibodies to cachectin/tumor necrosis factor reduce interleukin lb and interleukin 6 appearance during lethal bacteremia. J Exp Med 1989; 170: 1627–33.

    Article  PubMed  CAS  Google Scholar 

  21. Gebran SI, Yamamoto Y, Newton C, Klein TW, Friedman H. Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxyge species, bitric oxide, tryptophan, and iron (Ill). Infect Immun 1994; 62: 3197–205.

    PubMed  CAS  Google Scholar 

  22. Girardin E, Grau GE, Dayer J-M, Roux-Lombard P. The J5 Study Group, Lambert P-H. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 1988; 319: 397–400.

    Article  PubMed  CAS  Google Scholar 

  23. Green SJ, Nacy CA. L-arginine-derived nitric oxide is an antimicrobial effector molecule. ASM News 1994; 60: 836.

    Google Scholar 

  24. Grossberg SE, Burleson G, Morahan P, Jameson P. A bacterial protein inducing antiviral resistance and high titres of interferon. Progr Immunobiol Standard 1972; 5: 274–8.

    CAS  Google Scholar 

  25. Hack CE, De Groot EER, Felt-Bersma RJF, Nuijens JH, Van Schijndel RJMS, Eerenberg-Belmer AJM, Thijs LG, Aarden LA. Increased plasma levels of interleukin-6 in sepsis. Blood 1989; 74: 1704–10.

    PubMed  CAS  Google Scholar 

  26. Hack CE, Hart M, Van Schijndel RIMS, Eerenberg AJM, Nuijens JH, Thijs LG, Aarden LA. Infect Immunol 1992; 60: 2835–42.

    CAS  Google Scholar 

  27. Havell EA. Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol 1989; 143: 2894–9.

    PubMed  CAS  Google Scholar 

  28. Hershman MI, Polk HC Jr, Pietsch JD, Kuftinec D, Sonnenfeld G. Modulation of Klebsiella pneumonia infection of mice by interferon-gamma. Clin Exp Immunol 1988; 87: 406–9.

    Google Scholar 

  29. Hershman MI, Polk HC Jr, Pietsch JD, Shields RE, Wellhausen SR, Sonnenfeld G. Modulation of infection by gamma interferon treatment following trauma. Infect Immun 1988; 56: 2412–6.

    PubMed  CAS  Google Scholar 

  30. Hershman MI, Sonnenfeld G, Mays BW, Fleming F, Trachtenberg LS, Polk HC Jr. Effects of interferon-7 treatment on surgically simulated wound infection in mice. Microbiol Pathogenesis 1988; 4: 165–8.

    Article  CAS  Google Scholar 

  31. Hershman MJ, Pietsch JD, Trachtenberg L, Mooney THR, Shields RE, Sonnenfeld G. Protective effect of recombinant human tumor necrosis factor-a against surgically simulated wound infection in mice. Brit J Surg 1989; 76: 1282–6.

    Article  PubMed  CAS  Google Scholar 

  32. Hggasen AKM, Abrahamsen TG. Increased C3 production in human monocytes after stimulation with Candida albicans is suppressed by granulocyte-macrophages colony-stimulating factor. Infect Immun 1993; 61: 1779–85.

    Google Scholar 

  33. Hgglsen AKM, Hestdal K, Abrahamsen TG. Granulocyte-macrophage colony-stimulating factor suppresses basal and lypopolysaccharide-stimulated complement factor production in human monocytes. J Immunol 1993; 151: 3215–24.

    Google Scholar 

  34. Hopken U, Oppermann M, Montz H, Mohr M, Burchardi H, Gotze O. Treatment of septic shock in pigs with a monoclonal antibody with specificity for a c5a-neoepitope. Immunobiology 1992; 184: 430 (Abstract).

    Google Scholar 

  35. Izadkah Z, Mandel AD, Sonnenfeld G. Effect of treatment of mice with sera containing gamma interferon on the course of infection with Salmonella typhimurium strain LT-2. J Interferon Res 1980; 1: 137–45.

    Article  Google Scholar 

  36. Kagaya K, Watanabe K, Fukazawa Y. Capacity of recombinant gamma interferon to activate macrophages for Salmonella-killing activity. Infect Immun 1989; 57: 609–15.

    PubMed  CAS  Google Scholar 

  37. Kiderlen AF, Kaufmann SHE, Lohmann-Mathes ML. Protection of mice against intracellular bacterium L. monocytogenes by recombinant immune interferon. Eur J Immunol 1984; 14: 964–7.

    Article  PubMed  CAS  Google Scholar 

  38. Kuhn M, Goebel W. Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Liste-ria strains. Infect Immun 1994; 62: 348–56.

    PubMed  CAS  Google Scholar 

  39. Langermars JAM, Van Furth R. Cytokines and the host defense against Listeria monocytogenes and Salmonella typhimurium. Biotherapy 1994; 7: 169–79.

    Article  Google Scholar 

  40. Livingston DH, Malanoni MA, Sonnenfeld G. Immune enhancement by tumor necrosis factor-alpha improves antibiotic efficacy after hemorrhagic shock. J Trauma 1989; 29: 967–71.

    Article  PubMed  CAS  Google Scholar 

  41. Lloyd AR, Oppenheim JJ. Poly’s lament: the neglected role of the polymorphonuclear neutrophil in the affermit limb of the immune response. Immunol Today 1992; 13: 169–72.

    Article  PubMed  CAS  Google Scholar 

  42. Luoie A, Baltch AL, Smith RP, Franke MA, Ritz WJ, Singh JK, Gordon MA. Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis. Infect Immun 1994; 62: 2761–72.

    Google Scholar 

  43. Malangoni MA, Livingston DH, Sonnenfeld G, Polk HC Jr. Interferon gamma and tumor necrosis factor alpha. Use in Gram-negative infection after shock. Arch Surg 1990; 125: 444–6.

    PubMed  CAS  Google Scholar 

  44. Mancuso G, Tomasello F, Migliardo M, Delfino D, Cochran J, Cook JA, Teti G. Beneficial effects of interleukin-6 in neonatal mouse models of group B streptococcal disease. Infect Immun 1994; 62: 4997–5002.

    PubMed  CAS  Google Scholar 

  45. Mastroeni P, Arena A, Costa GB, Liberto MC, Bonina L, Hormaeche E. Serum TNFa in mouse typhoid and enhancement of a salmonella infection by anti-TNFa antibodies. Microbial Pathogenesis 1991; 11: 33–8.

    Article  PubMed  CAS  Google Scholar 

  46. Mathison JC, Wolfson E, Ulevitch RJ. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest 1988; 81: 1925–37.

    Article  PubMed  CAS  Google Scholar 

  47. Matsumura H, Onozuka K, Terada Y, Nakano Y, Nakano M. Effect of mucine recombinant interferon-7 in the protection of mice against Salmonella. Int J Immunopharmac 1990; 12: 49–56.

    Article  CAS  Google Scholar 

  48. Muotiala A, Mtikelä PH. The role of IFN-y in mutine Salmonella typhimurium infection. Microb Pathogenesis 1990; 8: 135–41.

    Article  CAS  Google Scholar 

  49. Muotiala A, Mäkelä PH. Role of ganuna interferon in late stages of murine salmonellosis. Infect Immun 1993; 61: 424853.

    Google Scholar 

  50. Nakano Y, Onozuka K, Terada Y, Shinomiya H, Nakano M. Protective effect of recombinant tumor necrosis factor-a in mucine salmonellosis. J Immunol 1990; 144: 1935–41.

    PubMed  CAS  Google Scholar 

  51. Nakano Y, Kasahara T, Mukaida N, Ko Y-C, Nakano M, Matsushima K. Protection against lethal bacterial infection in mice by monocyte-chemotactic and -activating factor. Infect Immun 1994; 62: 377–83.

    PubMed  CAS  Google Scholar 

  52. Nathan CF. Secretory products of macrophages. J Clin Invest 1987; 79: 319–26.

    Article  PubMed  CAS  Google Scholar 

  53. Nauciel C, Espinasse-Maes F. Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection. Infect Immun 1992; 60: 450–4.

    PubMed  CAS  Google Scholar 

  54. Ohlsson K, Björk P, Bergenfeldt M, Hageman R, Thompson RC. Interleukin 1 receptor antagonist reduces mortality from endotoxin shock. Nature 1990; 348: 550–2.

    Article  PubMed  CAS  Google Scholar 

  55. Paguirigan AM, Byrne GI, Becht S, Carlin JM. Cytokine-mediated indoleamin 2,3-dioxygenase induction in response to Chlamydia infection in human macrophage cultures. Infect Immun 1994; 62: 1131–6.

    PubMed  CAS  Google Scholar 

  56. Parsonnet J, Gillis ZA. Production of tumor necrosis factor by human monocytes in response to toxic-shock-syndrome toxinl. J Infect Dis 1988; 158: 1026–33.

    Article  PubMed  CAS  Google Scholar 

  57. Pierangeli SS, Sonnenfeld G. Treatment of murine macrophages with mucine interferon-y and tunor necrosis factor-alpha enhances uptake and intracellular killing of Pseudomonas aeruginosa. Clin Exp Immunol 1993; 93: 165–71.

    Article  PubMed  CAS  Google Scholar 

  58. Polk HC Jr, Cheadle WG, Livingston DH, Rodriguez DH, Starko KM, Izu AE, Jaffe HS, Sonnenfeld G. A random prospective clinical trial to determine the efficacy of interferongamma in severely injured patients. Amer J Surg 1992; 163: 191–196.

    Article  PubMed  Google Scholar 

  59. Ramarathinam L, Shaban RA, Niesel DW, Klimpel GR. Interferon gamma (IFN-y) production by gut-associated lymphoid tissue and spleen following oral Salmonella typhimurium chalenge. Microbial Pathogenesis 1991; 11: 347–56.

    Article  PubMed  CAS  Google Scholar 

  60. Rank RG, Ramsey KH, Pack EA, Williams DM. Effect of gamma interferon on resolution of mucine Chlamydia) infection. Infect Immun 1992; 60: 4427–9.

    PubMed  CAS  Google Scholar 

  61. Remick DG. Cytokines and septic shock. In: Griffin GE, ed. Cytokines in infection. London: Ballière Tindall, 1994: 37–50.

    Google Scholar 

  62. Starnes HF, Pearce MK, Tewari A, Yim JH, Zou JC, Abrams JS. Anti IL-6 monoclonal antibodies protect against lethal Escherichia Coli infection and lethal tumor necrosis factora-challenge in mice. J Immunol 1990; 145: 4185–91.

    PubMed  CAS  Google Scholar 

  63. Stevens MG, Pugh GW Jr, Tabatabai LB. Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. Infect Immun 1992; 60: 4407–9.

    PubMed  CAS  Google Scholar 

  64. Summersgill JT, Powell LA, Buster BL, Miller RD, Ramirez JA. Killing of Legionella pneumophila by nitric oxide in gamma-interferon-activated macrophages. J Leukoc Biol 1992; 52: 625–9.

    PubMed  CAS  Google Scholar 

  65. Timmerman CP, Mattsson E, Martinez-Martinez L, De Graaf L, Van Strijp JAG, Verbrugh HA, Fleehr A. Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglucans. Infect Immun 1993; 61: 4167–72.

    PubMed  CAS  Google Scholar 

  66. Vacheron F, Guenounou M, Nauciel C. Adjuvant active peptidoglucans induce secretion of a cytotoxic factor by macrophages. In: Seidl PH, Schleifer KH, eds. Biological properties of peptidoglucan. New York: W. de Gruyter & Co., 1986: 395–400.

    Google Scholar 

  67. Van Dissel JT, Stikkelbroeck JJM, Michel BC, Van den Barselaar MTh, Leijh PVC, Van Furth R. Inability of recombinant interferon-y to activate the antibacterial activity of mouse peritoneal macrophages against Listeria monocytogenes and Salmonella typhimurium. J Immunol 1987; 139: 1673–8.

    PubMed  Google Scholar 

  68. Waage A. Production and clearance of tumor necrosis factor in rats exposed to endotoxin and dexamethasone. Clin Immunol Immunopathol 1987; 45: 348–55.

    Article  PubMed  CAS  Google Scholar 

  69. Waage A, Espevik T. Interleukin 1 potentiates the lethal effect of tumor necrosis factor/cachectin in mice. J Exp Med 1988; 167: 1987–92.

    Article  PubMed  CAS  Google Scholar 

  70. Waage A, Brandtzseg P, Halstensen A, Kierulf P, Espevik T. The complex pattern of cytokines in serum from patients with men ingococcal septic shock. J Exp Med 1989; 169: 333–8.

    Article  PubMed  CAS  Google Scholar 

  71. Waage A, Halstensen A, Shalaby R, Brandtzwg P, Kierulf P, Espevik T. Local production of tumor necrosis factor-a, interleukin-1, and interleukin-6 in meningococcal meningitis. Relation to inflammatory response. J Exp Med 1989; 170: 1859–67.

    Article  PubMed  CAS  Google Scholar 

  72. Waage A, Brandtzseg P, Espevik T, Halstensen A. Current understanding of the pathogenesis of Gram-negative shock. Infect Dis Clin North Amer 1991; 5: 781–91.

    CAS  Google Scholar 

  73. Waage A. Presence and involvement of TNF in septic shock. In: Bender B, ed. Tumor necrosis factors: The molecules and their emerging role in medicine. New York: Raven Press, 1992: 275–83.

    Google Scholar 

  74. Waage A, Redl H, Schlag G, Schade U. The cytokine network in sepsis II: IL-1 and IL-6. In: Schlag G, Redl H, eds. Pathophysiology of shock, sepsis and organ failure. Berlin: Springer Verlag, 1993: 491–501.

    Google Scholar 

  75. Waage A, Halstensen A, Espevik T, Brandtzæg P. Cytokines in meningococcal disease. In: Griffin GE, ed. Cytokines in infection. London: Ballière Tindall, 1994: 97–108.

    Google Scholar 

  76. Xiong H, Kawamura I, Nishibori T, Mitshuyama M. Cytokine gene expression in mice at an early stage of infection with various strains of Listeria spp. differing in virulence. Infect Immun 1994; 62: 3649–54.

    PubMed  CAS  Google Scholar 

  77. Yamamoto Y, Okubo S, Klein TW, Onozaki K, Saito T, Friedman H. Binding of Legionella pneumophila to macrophages increases cellular cytokine mRNA. Infect Immun 1994; 62: 3947–56.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Microbiology, Rikshospitalet, University of Oslo, Norway

    Miklos Degré

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  1. Miklos Degré
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Editors and Affiliations

  1. New Jersey’s University of the Health Sciences, Piscataway, NJ, USA

    S. Pestka

  2. Diagnostisch Centrum SSDZ, Delft, The Netherlands

    H. Schellekens

  3. Medizinische Hochschule Hannover, Hannover, Germany

    P. Von Wussow

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© 1996 Kluwer Academic Publishers

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Degré, M. (1996). Cytokines and bacterial infections. In: Pestka, S., Schellekens, H., Von Wussow, P. (eds) Cytokine Yearbook Volume 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1616-6_10

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  • DOI: https://doi.org/10.1007/978-94-009-1616-6_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7221-2

  • Online ISBN: 978-94-009-1616-6

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