Circadian variation in the incidence of transient myocardial ischemia

  • David Mulcahy
  • Henry Purcell
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 170)


For centuries biological circadian rhythms have been alluded to, however it is mainly in the past 10 years that major interest has been generated in the subject of circadian variations in cardiovascular physiological and pathophysiological processes. The stimulus for a rash of circadian studies resulted in part from a report by Muller et al. [1], resulting from an analysis of the MILIS (Multicenter Investigation for the Limitation of Infarct Size) study, that there was a significant peak in onset of acute myocardial infarction in the morning waking hours when compared with other times of the day, and a trough at night. This circadian variation has subsequently been confirmed in several studies of acute myocardial infarction [2–4], and corresponds with a similar circadian variation demonstrated for sudden cardiac death [5, 6], the incidence of which peaks in the morning waking hours.


Acute Myocardial Infarction Sudden Cardiac Death Circadian Variation Stable Coronary Artery Disease Myocardial Oxygen Demand 
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© Kluwer Academic Publishers 1996

Authors and Affiliations

  • David Mulcahy
  • Henry Purcell

There are no affiliations available

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