Circadian fluctuation of fibrinolytic factors in blood

Investigation, importance and clinical consequences
  • Felicita Andreotti
  • Alessandro Manzoli
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 170)


The system in blood which dissolves fibrin can be viewed as a “potential” mechanism which exerts a major effect only at sites of fibrin accumulation. The breakdown of fibrin deposits is, in fact, triggered by fibrin itself, as fibrin attracts the active enzyme tissue-type plasminogen activator (t-PA) and the inactive pro-enzyme plasminogen onto its surface [1]. There t-PA converts or “activates” plasminogen to plasmin. Plasmin in turn breaks the solid fibrin strands into soluble fragments typically containing two D domains or D-dimers (Figure 1).


Plasminogen Activator Circadian Rhythm Plasminogen Activator Inhibitor Fibrinolytic Activity Circadian Variation 
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© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Felicita Andreotti
  • Alessandro Manzoli

There are no affiliations available

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