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The cytoskeleton and epithelial function

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Epithelial Transport

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Abstract

The number of known and proposed functions of the cytoskeleton have grown dramatically since the first descriptions of these filamentous components of the cytoplasm. Clear evidence to support a role in cell shape and structure (a true expression of function based on the term skeleton) has been repeatedly produced. Other functions include motile processes (whether the cell or its parts are locomoting or specific cytoplasmic constituents are moving inside a static cell) and the anchoring of the cells to substrates and to each other or the gelling of the cytoplasm so that movement within the cell space is restricted. With regard to epithelial cells some of the most significant functions for the different cytoskeletal elements are the establishment of epithelial polarity (Chapter 3), the maintenance of cell and substrate junctions, the trafficking of cell membrane proteins to and from membrane domains, the anchoring of these transport proteins in the cell membrane and the role that the cytoskeleton could play in signal transduction and regulation of transport events. The purpose of this chapter is to describe selected examples of the wide array of proteins grouped under the broad heading of cytoskeleton, review the use of drugs that act on the cytoskeleton and discuss selected epithelial models where a picture is emerging as to the role that the cytoskeleton plays in transport.

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  1. Department of Physiology and Biophysics, University of Texas Medical Branch, 77555-0641, Galveston, Texas, USA

    Nancy K. Wills PhD , Luis Reuss MD  & Simon A. Lewis PhD ,  & 

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Mills, J.W. (1996). The cytoskeleton and epithelial function. In: Wills, N.K., Reuss, L., Lewis, S.A. (eds) Epithelial Transport. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1495-7_13

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  • DOI: https://doi.org/10.1007/978-94-009-1495-7_13

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