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Biomechanisms Regulating Growth and Development pp 137–173Cite as

Strategies for the discovery of insect control agents: exploitation of biomechanisms regulating insect development

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Part of the Beltsville Symposia in Agricultural Research book series (BSAR,volume 12)

Abstract

The development of environmentally acceptable methods of insect control reamins critical to agricultural productivity and profitability in developed and developing countries. In this laboratory we are attempting to exploit knowledge of endocrine regulation of larval-pupal transformation in the Lepidoptera to illustrate new paradigms for the development of insect control agents. One approach employed transition state theory to design powerful inhibitors of an esterase which specifically removes insect juvenile hormone and initiates pupation. Inhibition of this enzyme retards pupation. These inhibitors were used as affinity ligands to purify the enzyme. Injection of the enzyme disrupts normal insect development so methods to elicit precocious expression of the enzyme represents a second approach to developing control agents.

Keywords

  • Juvenile Hormone
  • Molar Refractivity
  • Cabbage Looper
  • Juvenile Hormone Titer
  • Hemolymph Protein

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. Departments of Entomology and Environmental Toxicology, University of Caifornia, Davis, CA, 95616, USA

    B. D. Hammock, L. G. Harshman, M. L. Philpott, A. Székács, J. A. Ottea, R. A. Newitt, V. J. Wroblewski, P. P. Halarnkar & T. N. Hanzlik

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  1. B. D. Hammock
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  2. L. G. Harshman
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  3. M. L. Philpott
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  4. A. Székács
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  7. V. J. Wroblewski
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  9. T. N. Hanzlik
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    Hammock, B.D. et al. (1988). Strategies for the discovery of insect control agents: exploitation of biomechanisms regulating insect development. In: Steffens, G.L., Rumsey, T.S. (eds) Biomechanisms Regulating Growth and Development. Beltsville Symposia in Agricultural Research, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1395-0_12

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    • DOI: https://doi.org/10.1007/978-94-009-1395-0_12

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