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Women at High Risk to Breast Cancer pp 27–39Cite as

Familial and Genetic Factors — New Evidence

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Part of the book series: Developments in Oncology ((DION,volume 57))

Abstract

Breast cancer is a major health problem and cause of anxiety in the United States [1] and in discussing familial breast cancer (FBC) and hereditary breast cancer (HBC), it is important that these terms be clearly defined. FBC and HBC are commonly used interchangeably by authors to describe clustering of breast cancer among the relatives of a breast cancer patient. However, it is essential to distinguish between the terms ‘familial’ and ‘hereditary’ when describing families where two or more relatives manifest breast cancer.

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References

  1. Silverberg, E., Lubera, J.A. (1988). Cancer statistics, 1988. Cancer J. Clin., 38, 5–22.

    Article  CAS  Google Scholar 

  2. Lynch, H.T. (1981). Genetics and Breast Cancer, Van Nostrand Reinhold, New York.

    Google Scholar 

  3. Lynch, H.T., Fain, P.R., Goldgar, D., et al. (1981). Familial breast cancer and its recognition in an oncology clinic. Cancer, 47, 2730–2739.

    Article  PubMed  CAS  Google Scholar 

  4. Petrakis, N.L., Ernster, V., King, M.-C. (1981). Breast cancer. In Schottenfeld, D.S. and Fraumeni, J.F. Jr, (eds.), Cancer Epidemiology and Prevention, Saunders, Philadelphia, 855–870.

    Google Scholar 

  5. Sattin, R.W., Rubin, G.L., Webster, L.A. et al. (1985). Family history and the risk of breast cancer. J. Amer. Med. Assoc., 253, 1908–1913.

    Article  CAS  Google Scholar 

  6. Ottman, R., Pike, M.C., King, M.-C., Casagrande, J.T., Henderson, B.E. (1986). Familial breast cancer in a population-based series. Amer. J. Epidem., 123, 15–21.

    CAS  Google Scholar 

  7. Go, R.C.P., King, M.-C., Bailey-Wilson, J., Elston, R.C., Lynch, H.T. (1983). Genetic epidemiology of breast and associated cancers in high risk families, Part I.J. Nat. Cancer Inst., 71 455–462.

    PubMed  CAS  Google Scholar 

  8. Lynch, H.T., Krush, A.H., Lemon, H.M. et al. (1972). Tumor variation in families with breast cancer. J. Amer. Med. Ass., 222, 1631–1635.

    Article  CAS  Google Scholar 

  9. Lynch, H.T., Harris, R.E., Organ, C.H. et al. (1978) Familial association of breast/ovarian cancer. Cancer, 41, 1543–1548.

    Article  PubMed  CAS  Google Scholar 

  10. Lynch, H.T., Krush, A.J., Guirgis, H. (1973). Genetic factors in families with combined gastrointestinal and breast cancer. Amer. J. Gastroent., 59, 31–40.

    PubMed  CAS  Google Scholar 

  11. Lynch, H.T., Guirgis, H., Brodkey, F. et dl. (1976). Early age of onset in familial breast cancer. Arch. Surg., 111, 126–131.

    PubMed  CAS  Google Scholar 

  12. Haagensen, C.D., Haagensen, D.E. Jr, Bodian, C. (1981). Risk and Detection of Breast Cancer, Saunders, Philadelphia, 10–13.

    Google Scholar 

  13. Harris, R.E., Lynch, H.T., Guirgis, H.A. (1978). Familial breast cancer: risk to the contralateral breast. J. Nat. Cancer Inst., 60 955–960.

    PubMed  Google Scholar 

  14. Lynch, H.T., Albano, W.A., Layton, M.A., Kimberling, W.J., Lynch, J.F. (1984). Breast cancer, genetics, and age at first pregnancy. J. Med. Genet. 21, 96–98.

    Article  PubMed  CAS  Google Scholar 

  15. Lynch, H.T., Watson, P., Conway, T., Fitzsimmons, M.L., Lynch, J.F. (in press), (1988). Breast cancer family history as a risk factor for early onset breast cancer. Brit. Cancer Res. Treat.

    Google Scholar 

  16. Lynch, H.T., Mulcahy, G.M., Harris, R.E. et al. (1978). Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma. Cancer, 41, 2055–2064.

    Article  PubMed  CAS  Google Scholar 

  17. Lynch, H.T., Katz, D.A., Bogard, P.J., Lynch, J.F. (1985). The sarcoma, breast cancer, lung cancer, and adrenocortical carcinoma syndrome revisited; childhood cancer. Amer J. Dis. Child., 139, 134–136.

    PubMed  CAS  Google Scholar 

  18. King, M.-C., Go, R.C.P., Bailey-Wilson, ?? et al. (1983). Genetic epidemiology of breast and associated cancers in high risk families, Part II. J. Nat. Cancer Inst., 71, 463.

    PubMed  CAS  Google Scholar 

  19. Albano, W.A., Recabaren, J.A., Lynch, H.T. et al. (1982). Natural history of hereditary cancer of the breast and colon. Cancer, 50, 360–363.

    Article  PubMed  CAS  Google Scholar 

  20. Lynch, H.T., Albano, W.A., Danes, B.S. et al. (1984). Genetic predisposition to breast cancer. Cancer, 53, 612–622.

    Article  PubMed  CAS  Google Scholar 

  21. Lynch, H.T., Lynch, J.F. (1986). Breast cancer genetics in an oncology clinic: 328 consecutive patients. Ca. Genet. Cytogenet., 22, 369–371.

    Article  CAS  Google Scholar 

  22. DuPont, W.D., Page, D.L. (1985). Risk factors for breast cancer in women with proliferative breast disease. N. Engl. J. Med., 312, 146–151.

    Article  PubMed  CAS  Google Scholar 

  23. DuPont, W.D., Page, D.L. (1987). Breast cancer risk associated with proliferative disease, age at first birth, and a family history of breast cancer. Amer. J. Epidem., 125, 769–779.

    CAS  Google Scholar 

  24. Page, D.L., DuPont, W.D., Rogers, L.W., Rados, M.S. (1985). Atypical hyperplastic lesions of the female breast: a long term followup study. Cancer, 55, 2698–2708.

    Article  PubMed  CAS  Google Scholar 

  25. Rosen, P.P., Holmes, G., Lesser, M.L., Kinne, D.W., Beattie, E.J. (1985). Juvenile papillomatosis and breast carcinoma. Cancer, 55, 1345–1352.

    Article  PubMed  CAS  Google Scholar 

  26. Lagios, M.D., Rose, M.R., Margolin, F.R. (1980). Tubular carcinoma of the breast: association with multicentricity, bilaterality, and family history of mammary carcinoma.Amer. J. Clin. Path., 23, 25–30.

    Google Scholar 

  27. Anderson, D.E. (1974). Genetic study of breast cancer: identification of a high risk group. Cancer, 34, 1090–1097.

    Article  PubMed  CAS  Google Scholar 

  28. Rosen, P.P., Lesser, M.L., Senie, R.T., Kinne, D.W. (1982). Epidemiology of breast carcino- ma, III. A clinicopathologic study with a 10 year followup. Cancer, 50, 171–179.

    Article  PubMed  CAS  Google Scholar 

  29. Mulcahy, G.M., Platt, R. (1982). Pathologic aspects of familial carcinoma of the breast. In H.T. Lynch (ed.), Genetics and Breast Cancer, Van Nostrand Reinhold, New York, 65.

    Google Scholar 

  30. Marcus, J., Page, D., Watson, P., Conway, T., Lynch, XX (1988). High mitotic grade in hered- itary breast cancer. Lab. Invest., 58, 61A.

    Google Scholar 

  31. Ridolfi, R.L., Rosen, P.P., Port, A. et al. (1977). Medullary carcinoma of the breast. Cancer, 40, 1365–1385.

    Article  PubMed  CAS  Google Scholar 

  32. Fishman, J., Bradlow, H.L., Fukushima, D. et al. (1983). Abnormal estrogen conjugation in women at risk for familial breast cancer is concentrated at the periovulatory stage of the menstrual cycle. Cancer. Res., 43, 1884–1890.

    PubMed  CAS  Google Scholar 

  33. Al-Sumidaie, A.M., Leinster, S.J., Hart, C.A., Green, C.D., McCarthy, K. (1988). Particles with properties of retrovirus in monocytes from patients with breast cancer. Lancet, i, 5–8.

    Article  Google Scholar 

  34. Lidereau, R., Escot, C., Theillet, C., et al. (1986). High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients. J. Nat. Cancer Inst., 77, 697–701.

    PubMed  CAS  Google Scholar 

  35. Lynch, H.T., Watson, P., Marcus, J.N. et al. (1987). Hereditary breast cancer: search for bio- markers. J. Tam. Mark. Onc., 2, 153. 159.

    Google Scholar 

  36. Sandberg, A.A.,(1980). The Chromosomes in Human Cancer and Leukemia,Elsevier, New York, 485.

    Google Scholar 

  37. Trent, J.M. (1985). Cytogenetic and molecular biologic alterations in human breast cancer: a review. Brit. Cancer Res. Treat., 5, 221–229.

    Article  CAS  Google Scholar 

  38. Ferti-Passantonopoulou, A.D., Panini, A.D. (1987). Common cytogenetic findings in primary breast cancer. Ca. Genet. Cytogenet., 27, 289–298.

    Article  CAS  Google Scholar 

  39. Lundberg, C., Skoog, L., Cavenee, W.K., Nordenskjold, M. (1987). Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on choromosome 11. Proc. Nat. Acad. Sci., Wash, 84, 2372–2376.

    CAS  Google Scholar 

  40. Lynch, H.T., Conway, T., Watson, P., Schreiman, J., Fitzgibbons, R.J. Jr (1988). Extremely early onset hereditary breat cancer (HBC): surveillance/management implications. Neb. Med. J., 73, 97–100.

    CAS  Google Scholar 

  41. Eddy, D., Hasselblad, V., McGivney, W., Hendee, W. (1988). The value of mammography screening in women under age 50 years. J. Amer. Med. Ass., 259, 1512–1519.

    Article  CAS  Google Scholar 

  42. Committee of the Biological Effects of Ionizing Radiations (1980). The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980),National Academy Press, 269–285.

    Google Scholar 

  43. Holland, R., Hendricks, J.H.C., Mravunac, M. (1983). Mammographically occult breast cancer. Cancer, 52, 1810–1819.

    Article  PubMed  CAS  Google Scholar 

  44. Fitzgibbons, R.J. Jr., Anthone, G. (1987). Changing concepts in the surgical treatment of pa- tients with curable breast cancer. In Lynch, H.T., Kullander, S. (eds.), Cancer Genetics in Women, CRC Press, Boca Raton.

    Google Scholar 

  45. Lynch, H.T., Conway, T., Fitzgibbons, R.J. Jr. et al. Age of onset heterogeneity in hereditary breast cancer, Parts I and II. Submitted to Brit. Cancer Res. Treat.

    Google Scholar 

  46. Goodnight, J.E. Jr, Quagliana, J.M., Morton, D.L. (1984). Failure of subcutaneous mastec- tomy to prevent the development of breast cancer. J. Surg. One., 26, 198–201.

    Article  Google Scholar 

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Authors
  1. Henry T. Lynch
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  2. Joseph N. Marcus
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  3. Patrice Watson
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  4. Jane F. Lynch
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Editor information

Editors and Affiliations

  1. St. Thomas’Hospital and to Joint Breast Clinic, Royal Free Hospital, London, UK

    Basil A. Stoll (Honorary Consultant Physician to Oncology Department) (Honorary Consultant Physician to Oncology Department)

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© 1989 Kluwer Academic Publishers

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Lynch, H.T., Marcus, J.N., Watson, P., Lynch, J.F. (1989). Familial and Genetic Factors — New Evidence. In: Stoll, B.A. (eds) Women at High Risk to Breast Cancer. Developments in Oncology, vol 57. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1327-1_3

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  • DOI: https://doi.org/10.1007/978-94-009-1327-1_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7091-1

  • Online ISBN: 978-94-009-1327-1

  • eBook Packages: Springer Book Archive

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