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Factors Modifying Clinical Manifestations of Acid-Base Disorders

  • G. M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 18)

Abstract

The clinical manifestations of any given acid-base disorder are not only determined by the magnitude of the acid-base disturbance, but are also considerably modified by any coexisting diseases that a patient may have, or drugs that are ingested. Accordingly the physician should never just look at the laboratory measurements of anion-gap and blood gas values, but assess the clinical condition of the patient as a whole.

Keywords

Cardiac Output Arterial Oxygen Saturation Cardiovascular Collapse Respiratory Alkalosis Cerebral Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rossen,R., et al., (1943), Acute arrest of cerebral circulation in man. ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 50, 510–528.Google Scholar
  2. 2.
    Cohen,P J., et al., (1967), Effects of hypoxia on cerebral blood flow and metabolism in conscious man. JOURNAL OF APPLIED PHYSIOLOGY, 23, 183–189.PubMedGoogle Scholar
  3. 3.
    Refsum,H.E., et al., (1963), Relationship between state of consciousness and arterial hypoxaemia in patients with pulmonary insufficiency breathing air. CLINICAL SCIENCE, 25, 361–367.PubMedGoogle Scholar
  4. 4.
    Meyer,J.S., et al., (1965), Effects of anoxia on cerebral metabolism and electrolytes in man. NEUROLOGY, 15, 892–901.PubMedGoogle Scholar
  5. 5.
    Gotoh,F., et al., (1965), Cerebral effects of hyperventilation in man. ARCHIVES OF NEUROLOGY, 12, 410–423.PubMedGoogle Scholar
  6. 6.
    Hearse,D J., (1979), Oxygen deprivation and early myocardial contractile failure: A reassessment of the possible role of adenosine triphosphate. AMERICAN JOURNAL OF CARDIOLOGY, 44, 1115–1121.PubMedCrossRefGoogle Scholar
  7. 7.
    Katz,A.M., (1973), Effects of ischemia on the contractile processes of the heart muscle. AMERICAN JOURNAL OF CARDIOLOGY, 32, 456–460.PubMedCrossRefGoogle Scholar
  8. 8.
    Horvath,S.M., et al., (1943), Effects on man of severe oxygen lack. AMERICAN JOURNAL OF PHYSIOLOGY, 138, 659–668.Google Scholar
  9. 9.
    Bretschneider,H.J., et al., (1957), Uber den kritischen Wert und die physiologische Abhangigkeit der Sauerstoff-Sattiging des venoses Coronarblutes. PFLUGERS ARCHIV. GES. PHYSIOL. 264, 399–423.Google Scholar
  10. 10.
    Khambatta,HJ., Sullivan,S.F.,(1973), Effects of respiratory alkalosis on oxygen consumption and oxygenation. ANESTHESIOLOGY, 38, 53–58.PubMedCrossRefGoogle Scholar
  11. 11.
    Rastegar,H., et al., (1979), Respiratory alkalosis increases tissue oxygen demand. JOURNAL OF SURGICAL RESEARCH, 26, 687–692.PubMedCrossRefGoogle Scholar
  12. 12.
    Frumin,M.J., et al., (1959), Apneic oxygenation in man. ANESTHESIOLOGY, 20, 789–798.PubMedCrossRefGoogle Scholar
  13. 13.
    Comroe,J.H., Dripps,R.D., (1946), Artificial respiration. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 130, 381–383.PubMedGoogle Scholar
  14. 14.
    Wollman,H., et al., (1968), Effects of extremes of respiratory and metabolic alkalosis on carotid blood flow in man. JOURNAL OF APPLIED PHYSIOLOGY, 24, 60–65.PubMedGoogle Scholar
  15. 15.
    Wilson,R.F., et al., (1972), Severe alkalosis in critically ill surgical patients. ARCHIVES OF SURGERY, 105, 197–203.PubMedGoogle Scholar
  16. 16.
    Lawson,W.H., (1966), Interrelation of pH, temperature, and oxygen on deoxygenation rate of red cells. JOURNAL OF APPLIED PHYSIOLOGY, 21, 905–914.PubMedGoogle Scholar
  17. 17.
    Morgan,B.C, et al., (1966), Hemodynamic effects of intermittent positive pressure respiration. ANESTHESIOLOGY, 27, 584–590.PubMedCrossRefGoogle Scholar
  18. 18.
    Annat,G., et al., (1983), Effect of PEEP ventilation on renal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins, ANESTHESIOLOGY, 58, 136–141.PubMedCrossRefGoogle Scholar
  19. 19.
    Prys-Roberts,C., et al., (1968), Hemodynamics and alveolar- arterial PO2 differences at varying PaO2 in anaesthetized man. JOURNAL OF APPLIED PHYSIOLOGY, 25, 80–87.PubMedCrossRefGoogle Scholar
  20. 20.
    Richardson,D.W., et al., (1972), Systemic circulatory responses to hypocapnia in man. AMERICAN JOURNAL OF PHYSIOLOGY, 223, 1308–1312.PubMedGoogle Scholar
  21. 21.
    Cullen,D J., Eger,E.I., (1974), Cardiovascular effects of carbon dioxide in man. ANESTHESIOLOGY, 41, 345–349.PubMedCrossRefGoogle Scholar
  22. 22.
    Nahas,G.G., Cavert,H.M., (1957), Cardiac depressant effect of CO2 and its reversal. AMERICAN JOURNAL OF PHYSIOLOGY, 190, 483–491.PubMedGoogle Scholar
  23. 23.
    Euler, von U.S., Lishajko,F., (1963), Influence of pH on uptake and release of noradenaline in adrenergic nerve granules. JOURNAL OF NEUROCHEMISTRY, 10, 145–149.CrossRefGoogle Scholar
  24. 24.
    Nahas,G.G., et al., (1967), Acidemia and catecholamine output in the isolated canine adrenal gland. AMERICAN JOURNAL OF PHYSIOLOGY, 213, 1186–1192.PubMedGoogle Scholar
  25. 25.
    Tenney,S.M., (1956), Sympatho-adrenal stimulation by carbon dioxide and the inhibitory effect of carbonic acid on epinephrine response. AMERICAN JOURNAL OF PHYSIOLOGY, 187, 341–346.PubMedGoogle Scholar
  26. 26.
    Darby,T.D., Watts,D.T., (1964), Acidosis and blood epinephrine levels in hemorrhagic hypotension. AMERICAN JOURNAL OF PHYSIOLOGY, 206, 1281–1284.PubMedGoogle Scholar
  27. 27.
    Fiorica,V., et al., (1969), Influence of blood pH on adrenomedullary response to hemorrhage. AMERICAN JOURNAL OF PHYSIOLOGY, 217, 1211–1215.PubMedGoogle Scholar
  28. 28.
    Beierholm,E.A., et al., (1975), Effects of acid-base changes, hypoxia, and catecholamines on ventricular performance. AMERICAN JOURNAL OF PHYSIOLOGY, 228, 1555–1561.PubMedGoogle Scholar
  29. 29.
    Waddell,W.J., Bates,R.J., (1969), Intracellular pH. PHYSIOLOGICAL REVIEWS, 49, 285–329.PubMedGoogle Scholar
  30. 30.
    Poole-Wilson,P.A., Cameron,I.R.,(1975), Intracellular pH and K + of cardiac and skeletal muscle in acidosis and alkalosis. AMERICAN JOURNAL OF PHYSIOLOGY, 229, 1305–1310.PubMedGoogle Scholar
  31. 31.
    Hillered,L., et al., (1984), Influence of in-vitro lactic acidosis and hypercapnia on respiratory activity of isolated rat brain mitochondria. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 4, 430–437PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • G. M. Woerlee
    • 1
  1. 1.Department of AnaesthesiaUniversity Hospital of LeidenThe Netherlands

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