Vasoactive and Cardioactive Drugs

  • G. M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 18)


The cardiovascular function of a patient during the perioperative period is sometimes so compromised that either vasoactive or cardioactive drugs are required to restore or maintain acceptable haemodynamics. A large number of these drugs are available. Knowledge of the effects of these drugs on the cardiovascular system is an absolute requirement for the selection of the most appropriate drug, or drug combination.


Cardiac Output Sodium Nitroprusside Hemodynamic Effect Vasoconstrictor Drug Inotropic Drug 
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  1. 1.
    Denlinger, J.K., et al.,(1975), Cardiovascular responses to calcium administered intravenously to man during halothane anesthesia. ANESTHESIOLOGY, 42, 390–397.PubMedCrossRefGoogle Scholar
  2. 2.
    Scheidegger, D., et al.,(1980), Role of the systemic vasculature in the hemodynamic response to changes in plasma ionized calcium. ARCHIVES OF SURGERY, 115, 206–211.PubMedGoogle Scholar
  3. 3.
    Sebel, P.S., et al.,(1982), Cardiovascular effects of alfentanil anaesthesia. BRITISH JOURNAL OF ANAESTHESIA, 54, 1129.CrossRefGoogle Scholar
  4. 4.
    Richards, D.A., richard, B.N.C.,(1978), Concurrent antagonism of isoproteranol and norepinephrine after labetalol. CLINICAL PHARMACOLOGY AND THERAPEUTICS, 23, 253–258.Google Scholar
  5. 5.
    Silverberg, A.B., et al.,(1978), Norepinephrine: Hormone and neurotransmitter in man. AMERICAN JOURNAL OF PHYSIOLOGY, 234, E252–E256.PubMedGoogle Scholar
  6. 6.
    Barnes, G.A., et al.,(1980), Circulating adrenaline and blood pressure:the metabolic effects and kinetics of infused adrenaline in man. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 10, 401–406.PubMedCrossRefGoogle Scholar
  7. 7.
    Clutter, W.E., et al.,(1980), Epinephrine plasma clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. JOURNAL OF CLINICAL INVESTIGATION, 66, 94–101.PubMedCrossRefGoogle Scholar
  8. 8.
    Cohn, J.N.,(1965), Comparative cardiovascular effects of tyramine, ephedrine and norepinephrine in man. CIRCULATION RESEARCH, 16,174–182.PubMedGoogle Scholar
  9. 9.
    Engberg, G., Wicklund, L.,(1978), The circulatory effects of intravenously administered ephedrine during epidural anaesthesia. ACTA ANAESTHESIOLOGICA SCANDINAVICA, suppl. 66, 27–36.PubMedCrossRefGoogle Scholar
  10. 10.
    Aviado, D.M.,(1959), Cardiovascular effects of some commonly used pressor amines. ANESTHESIOLOGY, 20, 71–97.PubMedCrossRefGoogle Scholar
  11. 11.
    Smith, N.T., Corbascio, A.N.,(1970), The use and misuse of pressor agents. ANESTHESIOLOGY, 33, 58–101.PubMedCrossRefGoogle Scholar
  12. 12.
    Kersting, F., et al,(1976), A comparison of the cardiovascular effects of dobutamine and isoprenaline after open heart surgery. BRITISH HEART JOURNAL, 38, 622–626.PubMedCrossRefGoogle Scholar
  13. 13.
    Leier, C.V., et al.,(1978), Comparative systemic and regional hemodynamic effects of dopamine and dobutamine in patients with cardiomyopatnic heart failure. CIRCULATION, 58, 466–475.PubMedGoogle Scholar
  14. 14.
    Wilson, R.F., et al.,(1976), Hemodynamic effects of dopamine in critically ill septic patients. JOURNAL OF SURGICAL RESEARCH, 20,163–172.PubMedCrossRefGoogle Scholar
  15. 15.
    Jarnberg, P.O., et al.,(1981), Dopamine infusion in man. Plasma catecholamine levels and pharmacokinetics. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 25, 328–331.PubMedCrossRefGoogle Scholar
  16. 16.
    Goldstein, R.A., et al.,(1980), A comparison of digoxin and dobutamine in patients with acute infarction and cardiac failure. NEW ENGLAND JOURNAL OF MEDICINE, 303, 846–850.PubMedCrossRefGoogle Scholar
  17. 17.
    Sivarajan, M., et al.,(1980), Blood pressure, not cardiac output, determines blood loss during induced hypotension. ANESTHESIA AND ANALGESIA, 59, 203–206.PubMedCrossRefGoogle Scholar
  18. 18.
    Ludden, T.M., et al.,(1982), Clinical pharmacokinetics of hydralazine. CLINICAL PHARMACOKINETICS, 7, 185–205.PubMedCrossRefGoogle Scholar
  19. 19.
    Greenberg, B.H., et al.,(1978), Beneficial effects of hydralazine in severe mitral regurgitation. CIRCULATION, 58, 273–279.PubMedGoogle Scholar
  20. 20.
    Misra, K.N., Kezdi, P.,(1973), Hemodynamic effects of adrenergic stimulating and blocking agents in cardiogenic shock and low output state after myocardial infarction. AMERICAN JOURNAL OF CARDIOLOGY, 31, 724–735.PubMedCrossRefGoogle Scholar
  21. 21.
    Stern, M.A., et al.,(1978), Hemodynamic effects of intravenous phentolamine in low output cardiac failure. CIRCULATION, 58, 157–163.PubMedGoogle Scholar
  22. 22.
    Kelly, D.T., et al.,(1973), Use of phentolamine in acute myocardial infarction associated with hypertension and left ventricular failure. CIRCULATION, 47, 729–735.PubMedGoogle Scholar
  23. 23.
    Cope, D.H.P., Crawford, M.C.,(1979), Labetalol in controlled hypotension. Administration of labetalol when adequate hypotension is difficult to achieve. BRITISH JOURNAL OF ANAESTHESIA, 51, 359–365.PubMedCrossRefGoogle Scholar
  24. 24.
    McNiel, J.J., Louis, W.J.,(1984), Clinical pharmacokinetics of labetalol. CLINICAL PHARMACOKINETICS, 9, 157–167.PubMedCrossRefGoogle Scholar
  25. 25.
    Mutch, W.A.C., et al.,(1982), Hemodynamic effects of intravenous nitroglycerin: Importance of the delivery system. ANESTHESIA AND ANALGESIA, 61, 927–932.PubMedCrossRefGoogle Scholar
  26. 26.
    Armstrong, P.W., et al.,(1980), Pharmacokinetic-hemodynamic studies of intravenous nitroglycerin in congestive cardiac failure. CIRCULATION, 62, 160–166.PubMedGoogle Scholar
  27. 27.
    Gravenstein, J.S., et al.,(1964), Effects of atropine and scopolamine on the cardiovascualr system in man. ANESTHESIOLOGY, 25, 123–130.PubMedCrossRefGoogle Scholar
  28. 28.
    Mutch, W.A.C., Ringaert, K.R.A.,(1987), Effects of haemorrhage and phenylephrine on cerebral blood flow in rat during isoflurane anaesthesia. CANADIAN JOURNAL OF ANAESTHESIA, 34, sl06–sl07.Google Scholar
  29. 29.
    Bryan-Brown, C.W.,(1988), Blood flow to organs: Parameters for function and survival in critical illness. CRITICAL CARE MEDICINE, 16, 170–178.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • G. M. Woerlee
    • 1
  1. 1.Department of AnaesthesiaUniversity Hospital of LeidenThe Netherlands

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