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The Historical Role of Animal Experiments in the Development of Diphtheria Prophylaxis

  • Coenraad F. M. Hendriksen
Part of the Developements in Hematology and Immunology book series (DIHI, volume 20)

Abstract

In several respects the experimental work carried out over the decades to find a specific and reliable way of treating and preventing diphtheria determined the use of laboratory animals in the quality control of biological products in general. On the one hand, diphtheria was one of the first diseases where experimental animal research laid the foundation for combatting this disease (1, 2). On the other hand, many common routine procedures such as the determination of the efficacy of a vaccine and the use of a standard vaccine arose from diphtheria research. Before discussing the current method of vaccine production and control, attention will therefore be paid to the history of diphtheria prophylaxis and in particular to the significance of the animal experiment in this.

Keywords

Diphtheria Toxin Diphtheria Toxoid Potency Testing Corynebacterium Diphtheriae Potency Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Coenraad F. M. Hendriksen
    • 1
  1. 1.National Institute of Public Health and Environmental ProtectionThe Netherlands

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