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On the Role of Myocardial AMP-Deaminase

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Book cover Myocardial Energy Metabolism

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 91))

Abstract

In this chapter the AMP-deaminase activity in hearts of different species is compared with that in skeletal muscle. Some features of the well-characterized skeletal muscle enzyme, like binding to myosin filaments and deficiencies in humans, are described. Experimental models to study the role of cardiac AMP-deaminase, i.e., isolated enzyme, cardiomyocytes and isolated perfused heart, are discussed. Substrate saturation kinetics and regulatory effects of nucleotides, phosphate, and activated fatty acids are summarized; their significance for in vivo regulation considered. In addition the behavior of AMP-deaminase under various adenylate energy charges and its implications for the regulation of enzyme in ischemic tissue is examined. Myocardial AMP-deaminase is shown to be a tissue-specific isoenzyme, with different kinetic and regulatory forms. Developmental changes of AMP-deaminase and other enzymes of adenylate metabolism enzymes in myocardial cells are reviewed. The flux through the pathway catalyzed by AMP-deaminase in normoxic and ischemic heart is analyzed. A probable function of the reaction - preservation of purine nucleotides inside the myocardial cell - is proposed.

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  1. Department of Biochemistry, Academic Medical School Gdansk, Gdansk, Poland

    A. C. Skladanowski

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  1. Cardiochemical Laboratory, Thorax Center, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    Jan Willem De Jong

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© 1988 Kluwer Academic Publishers

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Skladanowski, A.C. (1988). On the Role of Myocardial AMP-Deaminase. In: De Jong, J.W. (eds) Myocardial Energy Metabolism. Developments in Cardiovascular Medicine, vol 91. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1319-6_6

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  • DOI: https://doi.org/10.1007/978-94-009-1319-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7087-4

  • Online ISBN: 978-94-009-1319-6

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