The Effect of Anesthetics on Myocardial Adenine Nucleotides

  • R. G. Merin
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 91)


The major interest in the effect of anesthetics on high-energy phosphates (adenine nucleotides) in the heart stems from the search for the mechanism of the negative inotropic effect of anesthetics and the interest in preserving myocardial energy during cardiac ischemia. Although the number of studies published is rather small, the results when the preparation has been stable are consistent. Anesthetics do not appear to change the concentration of high-energy phosphates in normal hearts. There is some evidence that barbiturates in high concentrations may interfere with myocardial energy synthesis and decrease high-energy phosphates in hypoxic or ischemic hearts and additional evidence that perhaps cardiac depressant anesthetics such as halothane may preserve high-energy phosphates in ischemic hearts. However, much more investigation is necessary in the ischemic heart in order to come to definite conclusions.


Creatine Phosphate Negative Inotropic Effect Thoracic Epidural Anesthesia Total Ischemia Ischemic Contracture 
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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • R. G. Merin
    • 1
  1. 1.Department of AnesthesiologyUniversity of Texas Medical School at HoustonHoustonUSA

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