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Cardioplegia and Calcium Entry Blockade

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Myocardial Energy Metabolism

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 91))

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Abstract

Cooling and induction of electromechanical arrest (cardioplegia) limit myocardial damage during open-heart operations. Many studies provide evidence for the use of calcium entry blockers, as adjuncts to cardioplegia to optimize the protection. This paper reviews their possible mechanism of action, application time, and efficacy during hypothermia. A major conclusion is that negative effects are virtually absent, apart from short-term negative inotropic responses. There is an increasing body of positive evidence for their efficacy. A new development is the use of these drugs for regional cardioplegia during dilation of coronary arteries (coronary angioplasty).

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  1. Cardiochemical Laboratory, Thoraxcenter, Erasmus, University Rotterdam, The Netherlands

    J. W. de Jong

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  1. Cardiochemical Laboratory, Thorax Center, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    Jan Willem De Jong

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© 1988 Kluwer Academic Publishers

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de Jong, J.W. (1988). Cardioplegia and Calcium Entry Blockade. In: De Jong, J.W. (eds) Myocardial Energy Metabolism. Developments in Cardiovascular Medicine, vol 91. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1319-6_24

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  • DOI: https://doi.org/10.1007/978-94-009-1319-6_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7087-4

  • Online ISBN: 978-94-009-1319-6

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