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Energy Metabolism of Adult Cardiomyocytes

  • Chapter
Myocardial Energy Metabolism

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 91))

  • 149 Accesses

Abstract

By now the basic features of the energy metabolism of isolated cardiomyocytes have been described. Unstimulated cardiomyocytes are quiescent and exhibit the characteristics of cardiac metabolism at basal energie demand. Their energetic demand, however, can be stimulated to the maximal rates of the physiological range. As oxidative substrates fatty acids are preferred to lactate and glucose. The uptake kinetics for these three substrates have been characterized. For glucose and lactate defined transport mechanisms are identified, for fatty acids a purely physical diffusion process is also discussed. Under anoxia, energy production falls short of energy supply. Already during the reversible phase of hypoxic injury, cardiomyocytes have some cytosolic enzyme release. It is hypothesized that both release of enzymes and development of rigor are causelly related to changes in the free energy change of cytosolic ATP hydrolysis rather than in absolute ATP concentrations. Loss of Ca2+ control follows energetic exhaustion At cytosolic Ca2+ levels beyond 3 uM, it becomes irreversible. In detail the relation between energy metabolism and onset of irreversible hypoxic cell injury is not sufficiently understood.

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Authors and Affiliations

  1. Physiologisches Institut I, Universität Düsseldorf, Düsseldorf, Germany

    H. M. Piper, B. Siegmund & R. Spahr

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  1. H. M. Piper
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  2. B. Siegmund
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  3. R. Spahr
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Editors and Affiliations

  1. Cardiochemical Laboratory, Thorax Center, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    Jan Willem De Jong

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© 1988 Kluwer Academic Publishers

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Piper, H.M., Siegmund, B., Spahr, R. (1988). Energy Metabolism of Adult Cardiomyocytes. In: De Jong, J.W. (eds) Myocardial Energy Metabolism. Developments in Cardiovascular Medicine, vol 91. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1319-6_15

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  • DOI: https://doi.org/10.1007/978-94-009-1319-6_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7087-4

  • Online ISBN: 978-94-009-1319-6

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