Light chain-related tubulointerstitial nephropathy
Renal failure remains a major complication of multiple myeloma, occurring in about half of the patients with this disease; its presence is associated with a markedly shortened patient survival [1, 2, 3]. Although several different renal lesions may develop, the one most commonly recognized is a tubulointerstitial nephropathy often referred to as ‘myeloma kidney’ . The characteristic features of this lesion include proximal tubule damage with atrophy and distal nephron cast formation. Bence Jones proteins (BJP), which are immunoglobulin LC’s in monomeric, dimeric, and aggregated forms, have been shown to be the most important association with renal failure [4, 5]. Also parenteral administration of LC’s has reproduced this tubulointerstitial lesion in mouse and rat models.
KeywordsMultiple Myeloma Proximal Tubule Proximal Convoluted Tubule Distal Nephron Bence Jones Protein
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- 5.Defronzo RA, Cooke CR, Wright JR, Humphrey RL. Renal function in patients with multiple myeloma. Medicine (Baltimore) 1978; 57: 151–66.Google Scholar
- 7.Sanders PW, Herrera GA. Galla JH. Human Bence Jones protein toxicity in rat proximal tubule ephithelium in vivo. Kidney Int 1987; 32 (in press).Google Scholar