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B lymphocyte activation and differentiation

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Immunopathogenetic Mechanisms of Arthritis

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Abstract

Dysregulation of antibody production by cells of the B-cell lineage is an important feature in rheumatoid arthritis and allied disorders, as argued elsewhere in this volume. In order better to understand the pathophysiology of the immune abnormalities associated with the rheumatic disorders, insight into the normal B-cell response and its regulation is crucial. To begin with the intricate connections of the humoral immune response with antigen-presenting cells (APC) and T-cells, the carriers of cell-mediated immunity, should be noted. Remarkable progress has been made in recent years in understanding the B-cell response and its regulation in genetic and molecular terms. Much is now known concerning the elegant process of genetic recombination that allows the creation of individually distinct receptor (immunoglobulin) molecules on B-cells.

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  1. C. J. M. Melief
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Editors and Affiliations

  1. Department of Rheumatology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK

    J. A. Goodacre  & W. Carson Dick  & 

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Melief, C.J.M. (1988). B lymphocyte activation and differentiation. In: Goodacre, J.A., Dick, W.C. (eds) Immunopathogenetic Mechanisms of Arthritis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1293-9_10

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  • DOI: https://doi.org/10.1007/978-94-009-1293-9_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7075-1

  • Online ISBN: 978-94-009-1293-9

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