The skin as a chemical barrier

  • J. D. Wilkinson


The skin is an incomplete barrier, water (and some gases) passing through it to some extent. It is also vulnerable to chemical attack.

This barrier property of skin has important therapeutic, toxico-logical and dermatological consequences1. In this paper, I shall concentrate solely on the skin as a chemical barrier in respect to irritants and potential sensitizers.


Stratum Corneum Barrier Function Irritant Contact Dermatitis Chemical Barrier Skin Surface Lipid 
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    Barry, B.W. (1983). Dermatological Formulations: Percutaneous Absorption. (New York: Marcel Dekker Inc.)Google Scholar
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    Malten, K.E. and den Arend, J.A. (1985). Irritant contact dermatitis. Traumiterative and cumulative impairment by cosmetics, climate, and other daily loads. Derm. Beruf. Umwelt., 33(4), 125PubMedGoogle Scholar
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    Willis, C.M., Young, E., Brandon, D.R. and Wilkinson, J.D. (1986). Immunopathological and ultrastructural findings in human allergic and irritant contact dermatitis. Br. J. Dermatol., 115, 305PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1988

Authors and Affiliations

  • J. D. Wilkinson

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