A critical review of percutaneous penetration studies

  • M. I. Foreman


As is evident from the variety of topics covered in this book, skin, as an organ, performs a number of diverse functions. One is to control the transport of physiologically important material to and from the body, and to prevent so far as possible the ingress of foreign substances. It is this role of skin as a barrier which is of prime interest here. Studies in this area contribute to the further understanding of the structure and function of skin, and have the additional practical importance that transdermal drug delivery has in some circumstances attractive advantages over other methods of drug administration1.


Stratum Corneum Diffusion Constant Triamcinolone Acetonide Percutaneous Absorption Skin Penetration 
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  1. 1.
    Barry, B.W. (1983). Dermatological Formulations, Percutaneous Absorption. (New York, Basel: Dekker)Google Scholar
  2. 2.
    McKenzie, A.W. and Stoughton, R.B. (1962). Method for comparing percutaneous absorption of steroids. Arch. Dermatol., 86, 608–610Google Scholar
  3. 3.
    Clanachan, I., Devitt, H.G., Foreman, M.I. and Kelly, I.P. (1980). The human vasoconstrictor assay for topical steroids. J. Pharmacal. Methods, 4, 209–220CrossRefGoogle Scholar
  4. 4.
    Barry, B.W. and Woodford, R. (1986). The vasoconstrictor test as a model for developing topical formulations. In (eds.) Marks, R. and Plewig, G. Skin Models. pp 103–112. (Berlin: Springer Verlag)Google Scholar
  5. 5.
    Stoughton, R.B., Clendenning, W.E. and Kruse, D. (1960). Percutaneous absorption of nicotinic acid and derivatives. J. Invest. Dermatol., 35, 337–341Google Scholar
  6. 6.
    Guy, R.H., Hadgraft, J. and Malbach, H.I. (1982). A pharmacokinetic model for percutaneous absorption. Int. J. Pharm., 11, 119–124CrossRefGoogle Scholar
  7. 7.
    Scheuplein, R.J. and Blank, I.H. (1973). Mechanisms of percutaneous absorption. IV. Penetration of non-electrolytes (alcohols) from aqueous solutions and from pure liquids. J. Invest. Dermatol., 66, 286–296CrossRefGoogle Scholar
  8. 8.
    Washitake, M., Yajima, T., Anmo, T., Arita, T. and Hori, R. (1973). Studies on percutaneous absorption of drugs. III. Percutaneous absorption of drugs through damaged skin. Chem. Pharm. Bull., 21, 2444–24451PubMedGoogle Scholar
  9. 9.
    Takeda, Y. (1975). An autoradiographic study on the percutaneous absorption of a topical corticosteroid with reference to the effects of occlusion and stripping. J. Dermatol., 2, 131–6PubMedGoogle Scholar
  10. 10.
    Tregear, R.T. (1961). Relative penetrability of hair follicles and epidermis. J. Physiol., 156, 307–13PubMedGoogle Scholar
  11. 11.
    Scheuplein, R.J. (1967). Mechanism of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration. J. Invest. Dermatol., 48, 79–88PubMedGoogle Scholar
  12. 12.
    Scheuplein, R.J. (1972). Properties of the skin as a membrane. In (eds.) Stoughton, R.B. and Van Scott, E.J. Pharmacology and the Skin. Chap. X, pp 125–152. (New York: Appleton-Century-Crofts)Google Scholar
  13. 13.
    Scheuplein, R.J. and Blank, I.H. (1971). Permeability of the skin. Physiol. Rev., 51, 702–747PubMedGoogle Scholar
  14. 14.
    Foreman, M.I., Picton, W., Lukowiecki, G.A. and Clark, C. (1979). The effect of topical crude coal tar on unstimulated hairless hamster skin. Br. J. Dermatol., 100, 707–715PubMedCrossRefGoogle Scholar
  15. 15.
    Foreman, M.I., Clanachan, I. and Kelly, I.P. (1983). Diffusion barriers in skin, a new method of comparison. Br. J. Dermatol., 108, 549–53PubMedCrossRefGoogle Scholar
  16. 16.
    Hsia, S.L. and Lee, H.Y. (1966). Metabolic transformations of cortisol-414C in human skin. Biochemistry, 5, 1469–74PubMedCrossRefGoogle Scholar
  17. 17.
    Hershey, F.B., Lewis Jr., C., Murphy, J. and Schiff, T. (1960). Quantitative histochemistry of human skin. J. Histochem. Cytochem., 8, 41–9PubMedCrossRefGoogle Scholar
  18. 18.
    Crank, J. (1970). The Mathematics of Diffusion. (Oxford: Oxford University Press)Google Scholar
  19. 19.
    Daynes, H. (1920). The process of diffusion through a rubber membrane. Proc. R. Soc., A97, 286–307Google Scholar
  20. 20.
    Berger, J.E. and Helm, F. (1970). Flurandrenolone tape. New means of achieving occlusive therapy. N. Y. State J. Med., 70, 406–408PubMedGoogle Scholar
  21. 21.
    Vickers, C.F.H. (1963). Existence of a reservoir in the stratum corneum — experimental proof. Arch. Dermatol., 88, 20–25PubMedGoogle Scholar
  22. 22.
    Scheuplein, R.J. and Ross, L.W. (1974). Mechanism of percutaneous absorption. V. Percutaneous absorption of solvent deposited solids. J. Invest. Dermatol., 62, 353–360PubMedCrossRefGoogle Scholar
  23. 23.
    Foreman, M.I. (1986). Stratum corneum hydration; consequences for skin permeation experiments. Drug. Dev. Ind. Pharm., 12, 461–463CrossRefGoogle Scholar
  24. 24.
    Foreman, M.I., Kelly, I. and Lukowiecki, G.A. (1977). A method for the measurement of diffusion constants suitable for studies of non-occluded skin. J. Pharm. Pharmacol., 29, 108–109PubMedCrossRefGoogle Scholar
  25. 25.
    Van Duzee, B.F. (1975). Thermal analysis of human stratum corneum. J. Invest. Dermatol., 65, 404–408PubMedCrossRefGoogle Scholar
  26. 26.
    Foreman, M.I. and Clanachan, I. (1984). Steroid diffusion and binding in human stratum corneum. J. Chem. Soc. Faraday Trans., 1, 80, 3439–3444Google Scholar
  27. 27.
    Feldman, R.J. and Maibach, H.I. (1965). Penetration of 14C-hydrocortisone through normal skin. Arch. Dermatol., 91, 661–666CrossRefGoogle Scholar

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© MTP Press Limited 1988

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  • M. I. Foreman

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