The electrophysiology of reperfusion- induced arrhythmias following acute myocardial ischaemia

  • N. A. Flores
  • D. J. Sheridan
Part of the Current Status of Clinical Cardiology book series (CSOCC, volume 6)


The observation that reperfusion of the ischaemic myocardium frequently leads to the development of ventricular arrhythmias has become well established from results obtained during experimental studies, and from clinical observations during reperfusion1-3. Much useful information has been obtained during the past decade; however, the precise mechanisms which induce these arrhythmias remain incompletely understood. Experimental studies have revealed for example that ventricular fibrillation may occur more frequently on reperfusion than during the preceding period of ischaemia4,5, however the arrhythmogenic effects of reperfusion, although intense, are short lived and this has made it difficult to provide direct evidence of their involvement in sudden cardiac death. As a result almost all of our understanding of the electrophysiological changes which are associated with the development of ventricular arrhythmias during reperfusion is based on the use of animal models. This chapter will attempt to consolidate these findings, and provide an insight into the mechanisms responsible for the arrhythmogenic effects of reperfusion.


Myocardial Ischaemia Ventricular Fibrillation Refractory Period Action Potential Duration Acute Myocardial Ischaemia 
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© Kluwer Academic Publishers 1988

Authors and Affiliations

  • N. A. Flores
  • D. J. Sheridan

There are no affiliations available

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