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Inflammatory Cells in Allergic Disease

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Mast Cells, Mediators and Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 7))

Abstract

Allergic diseases (evoked totally, or in part, by IgE-mediated mechanisms) affect many organs and tissues, but in particular the upper and lower respiratory tract, the eyes, the gastro-intestinal tract and the skin. The rapid release of mast cell-associated mediators probably accounts almost entirely for the clinical manifestations of immediate hypersensitivity, i.e. rhinorrhoea, nasal blockage, sneezing, wheeze, pruritus, abdominal discomfort and diarrhoea. After a single exposure to allergen these symptoms are self-limiting and usually subside spontaneously (Figure 8.1). With repeated exposure, a prominent local inflammatory response develops. This is associated with more prolonged and protracted symptoms such as bronchial irritability or hyperresponsiveness, permanent nasal congestion, indurated skin lesions and chronic mucoid diarrhoea. It should be borne in mind that mucus hypersecretion is a characteristic feature of inflammation at all mucosal surfaces.

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Authors
  1. A. B. Kay
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Editors and Affiliations

  1. Immunopharmacology Group, Clinical Pharmacology, University of Southampton, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

  2. Faculty of Medicine, Level D, Centre Block, Southampton General Hospital, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

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© 1988 Kluwer Academic Publishers

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Kay, A.B. (1988). Inflammatory Cells in Allergic Disease. In: Holgate, S.T. (eds) Mast Cells, Mediators and Disease. Immunology and Medicine Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1287-8_8

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  • DOI: https://doi.org/10.1007/978-94-009-1287-8_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7072-0

  • Online ISBN: 978-94-009-1287-8

  • eBook Packages: Springer Book Archive

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