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Experimental Models of Pulmonary and Joint Inflammation and Their Relevance to Man

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Eicosanoids in Inflammatory Conditions of the Lung, Skin and Joints

Part of the book series: Advances in Eicosanoid Research ((AEIR,volume 3))

  • 38 Accesses

Abstract

For ethical and practical considerations, the study of human disease processes has relied heavily on the use of experimental models in laboratory animals. Inflammation is no exception. By their very nature, the actual relevance of such models to the clinical situation, and consequently their likely predictive value, is open to question. With this point in mind, in this chapter, we will consider the relevance of a variety of experimental models of inflammation in which the contribution of eicosanoids has been investigated. We have chosen, as examples, animal models of asthma, other pulmonary diseases and rheumatoid arthritis.

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  1. A. N. Payne
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  1. Clinical Pharmacology Group, University of Southampton, SO9 4XY, Southampton, UK

    Martin Church  & Clive Robinson  & 

  2. Clinical Pharmacology Group, Southampton General Hospital, SO9 4XY, Southampton, UK

    Martin Church  & Clive Robinson  & 

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Payne, A.N., De Nucci, G., Pettipher, E.R. (1988). Experimental Models of Pulmonary and Joint Inflammation and Their Relevance to Man. In: Church, M., Robinson, C. (eds) Eicosanoids in Inflammatory Conditions of the Lung, Skin and Joints. Advances in Eicosanoid Research, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1283-0_9

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